中药可以治疗勃起功能障碍吗?

2009 2nd International Conference on Biomedical Engineering and Informatics Pub Date : 2009-10-30 DOI:10.1109/BMEI.2009.5304967

Chien-Yu Chen, D. Bau, M. Tsai, Y. Hsu, T. Ho, Hung-Jin Huang, Yea-Huey Chang, F. Tsai, Chang-Hai Tsai, Calvin Yu‐Chian Chen

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引用次数: 1

摘要

摘要:本研究表明，从淫羊藿(Epimedium sagittatum)成分中提取PDE5的有效抑制剂。Xia研究数据集的PDE 5抑制剂计算了它们的性质。采用多元线性回归分析建立QSAR模型。这些特性通过QSAR模型与药物活性相关联。结果与该QSAR模型的药物活性呈高度相关(R2 = 0.848)。这些属性的权重分别为-5.359、6.434、-3.959、5.149和8.689。在预测结果中，利用相关性预测ES系列的pIC50 (Cialis = 7.988, ES02 = 6.31, ES03a = 9.78, ES03b = 10.03)。采用对接协议对预测趋势进行了验证。该结果在对接评分上呈现相同趋势(Cialis = 53.271, ES02 = 57.864, ES03a = 64.260, ES03b = 76.915)。根据这些结果，ES03b被提升为PDE5的有效抑制剂。

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Could Traditional Chinese Medicine Used for Curing Erectile Dysfunction?

# Equal contribution Abstract—This study could show that the potent inhibitor of PDE5 from Epimedium sagittatum components. The PDE 5 inhibitors of data set from Xia's study were calculated their properties. Multiple linear regression analysis was used to build the QSAR model. Those properties were associated to drug activities by the QSAR model. This result showed high correlation (R2 = 0.848) with drug activities in this QSAR model. The weights of those properties were -5.359, 6.434, -3.959, 5.149, and 8.689. In the result of prediction, the correlation was employed to predict pIC50 of the ES series (Cialis = 7.988, ES02 = 6.31, ES03a = 9.78, ES03b = 10.03). The docking protocol was used to prove the trend of prediction. This result showed the same trend in docking scores (Cialis = 53.271, ES02 = 57.864, ES03a = 64.260, ES03b = 76.915). According to those results, ES03b was elevated to be a potent inhibitor of PDE5.

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2009 2nd International Conference on Biomedical Engineering and Informatics

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