类风湿性关节炎患者炎性小关节内注射甲氨蝶呤有无电穿孔的安全性

IF 1.9 Q2 ORTHOPEDICS
M. Tada, K. Inui, T. Okano, K. Mamoto, T. Koike, Hiroaki Nakamura
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引用次数: 4

摘要

类风湿关节炎(RA)患者的一般疾病活动度可以通过改善疾病的抗风湿药物得到很好的控制,但局部炎症往往停留在少数小关节。电穿孔,在细胞膜上形成小孔,已被证明对药物输送有用。在一项前瞻性、随机、双盲、安慰剂对照的探索性研究(UMIN000016606)中,研究了甲氨蝶呤(MTX)和电穿孔联合治疗类风湿关节炎局部关节炎症的安全性。患者被随机分为MTX联合电穿孔组(True-EP)和单独MTX组(False-EP)。在超声引导下将MTX溶液注入手指关节。True-EP组用MTX进行电穿孔,False-EP组给予MTX,但只使用电极夹紧。从基线到26周,对超声分级、疾病活动性和安全性进行评估。5例患者(3例真ep和2例假ep),平均年龄57.4岁,病程10.2年。3例(2例True-EP和1例False-EP)灰度等级不变,2例(1例True-EP和1例False-EP)灰度等级升高。3例(2例真ep, 1例假ep)疾病活动度减轻。没有患者出现皮肤烧伤或电击。电穿孔联合甲氨蝶呤治疗RA是安全的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Safety of Intra-articular Methotrexate Injection With and Without Electroporation for Inflammatory Small Joints in Patients With Rheumatoid Arthritis
The general disease activity of patients with rheumatoid arthritis (RA) is well controlled by disease-modifying antirheumatic drugs, but local inflammation often remains in a few small joints. Electroporation, making small pores in cell membranes, has proven useful for drug delivery. The safety of a combination therapy of methotrexate (MTX) and electroporation for local joint inflammation in RA was investigated in a prospective, randomized, double-blind, placebo-controlled, exploratory study (UMIN000016606). The patients were randomly allocated to groups receiving a combination of MTX and electroporation (True-EP) and MTX alone (False-EP) groups. The MTX solution was injected into finger joints under ultrasound guidance. The True-EP group underwent electroporation with MTX, and the False-EP group was given MTX but only pinched using the electrode. The ultrasound grade, disease activity, and safety were evaluated from baseline to 26 weeks. Five patients (3 True-EP and 2 False-EP) with a mean age of 57.4 years and disease duration of 10.2 years were enrolled. The grey-scale grade was unchanged in 3 cases (2 True-EP and 1 False-EP) and increased in 2 cases (1 True-EP and 1 False-EP). Disease activity was alleviated in 3 cases (2 True-EP and 1 False-EP). No patients experienced burned skin or electroshock. The combination therapy of electroporation and MTX was safe for RA patients.
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
14
审稿时长
8 weeks
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