细胞角蛋白染色检测局部晚期食管癌新辅助放化疗后食管切除术患者残留病变

M. Chadha, C. LeVea, T. Mashtare, G. Wilding, M. Javle, C. Nwogu
{"title":"细胞角蛋白染色检测局部晚期食管癌新辅助放化疗后食管切除术患者残留病变","authors":"M. Chadha, C. LeVea, T. Mashtare, G. Wilding, M. Javle, C. Nwogu","doi":"10.5580/17d1","DOIUrl":null,"url":null,"abstract":"Thirty percent of patients undergoing neoadjuvant chemoradiation therapy (neo-CRT) for locally advanced esophageal cancer achieve a complete pathologic response (CPR) based on standard Hematoxylin and Eosin staining (CPR-HE). There is controversy regarding the prognostic value of CPR-HE. Immunohistochemical staining may be useful to detect subtle microscopic residual disease in such patients. We undertook this present study to test this hypothesis. Eighteen consecutive patients who achieved CPR-HE were identified. Seven patients had positive cytokeratin staining; three had microscopic residual disease that was not identified on original hematoxylin-eosin sections. Three of the seven patients (43%) with positive cytokeratin staining had systemic relapse (60 % of patients with systemic relapse).Cytokeratin staining could be a useful adjunct to routine hemaoxylin-eosin staining to identify residual tumor in such patients. The prognostic significance of CPR-CK, however, needs to be validated in a large cohort.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"15 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cytokeratin Staining to Detect Residual Disease in Patients Undergoing Neoadjuvant Chemoradiation followed by Esophagectomy for Locally Advanced Esophageal Cancer\",\"authors\":\"M. Chadha, C. LeVea, T. Mashtare, G. Wilding, M. Javle, C. Nwogu\",\"doi\":\"10.5580/17d1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Thirty percent of patients undergoing neoadjuvant chemoradiation therapy (neo-CRT) for locally advanced esophageal cancer achieve a complete pathologic response (CPR) based on standard Hematoxylin and Eosin staining (CPR-HE). There is controversy regarding the prognostic value of CPR-HE. Immunohistochemical staining may be useful to detect subtle microscopic residual disease in such patients. We undertook this present study to test this hypothesis. Eighteen consecutive patients who achieved CPR-HE were identified. Seven patients had positive cytokeratin staining; three had microscopic residual disease that was not identified on original hematoxylin-eosin sections. Three of the seven patients (43%) with positive cytokeratin staining had systemic relapse (60 % of patients with systemic relapse).Cytokeratin staining could be a useful adjunct to routine hemaoxylin-eosin staining to identify residual tumor in such patients. The prognostic significance of CPR-CK, however, needs to be validated in a large cohort.\",\"PeriodicalId\":22534,\"journal\":{\"name\":\"The Internet Journal of Oncology\",\"volume\":\"15 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/17d1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/17d1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

根据标准苏木精和伊红染色(CPR- he), 30%的局部晚期食管癌患者接受新辅助放化疗(neo-CRT)达到完全病理缓解(CPR)。关于心肺复苏- he的预后价值存在争议。免疫组织化学染色可用于检测此类患者细微的显微残留病变。我们进行这项研究是为了验证这一假设。18例连续实现心肺复苏的患者被确认。7例患者细胞角蛋白染色阳性;3例有显微残留疾病,在原始苏木精-伊红切片上未发现。7例细胞角蛋白染色阳性的患者中有3例(43%)出现全身复发(60%的患者出现全身复发)。细胞角蛋白染色可作为常规血精-伊红染色的辅助手段,用于鉴别此类患者的残留肿瘤。然而,CPR-CK的预后意义需要在一个大的队列中得到验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cytokeratin Staining to Detect Residual Disease in Patients Undergoing Neoadjuvant Chemoradiation followed by Esophagectomy for Locally Advanced Esophageal Cancer
Thirty percent of patients undergoing neoadjuvant chemoradiation therapy (neo-CRT) for locally advanced esophageal cancer achieve a complete pathologic response (CPR) based on standard Hematoxylin and Eosin staining (CPR-HE). There is controversy regarding the prognostic value of CPR-HE. Immunohistochemical staining may be useful to detect subtle microscopic residual disease in such patients. We undertook this present study to test this hypothesis. Eighteen consecutive patients who achieved CPR-HE were identified. Seven patients had positive cytokeratin staining; three had microscopic residual disease that was not identified on original hematoxylin-eosin sections. Three of the seven patients (43%) with positive cytokeratin staining had systemic relapse (60 % of patients with systemic relapse).Cytokeratin staining could be a useful adjunct to routine hemaoxylin-eosin staining to identify residual tumor in such patients. The prognostic significance of CPR-CK, however, needs to be validated in a large cohort.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信