裸赤铁矿纳米颗粒和功能化赤铁矿纳米颗粒在模拟生物介质中的体内毒性和生物降解研究

IF 1.3 4区材料科学 Q3 MATERIALS SCIENCE, CERAMICS

Advances in Applied Ceramics Pub Date : 2021-07-25 DOI:10.1080/17436753.2021.1956292

Kanwal Akhtar, N. A. Shad, M. M. Sajid, Y. Javed, F. Muhammad, B. Akhtar, M. Irfan Hussain, A. Sharif, W. Abbas, A. Munawar

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引用次数: 3

摘要

采用共沉淀法合成了赤铁矿裸纳米粒子和功能化赤铁矿纳米粒子(NPs)，并用XRD、SEM、TEM、EDX、FTIR和VSM对其进行了表征。XRD证实了Fe2O3为菱形六方结构，TEM和SEM表征了颗粒尺寸在22 ~ 80 nm之间的片状NPs。VSM呈现软铁磁性。通过体内评估，分析白化病大鼠在通过腹腔给药途径给药裸NPs和包被NPs后不同研究天的血清水平变化。毒性参数在第1天短暂升高，之后逐渐降低。在生物降解研究中，NPs暴露于溶酶体样培养基中，在短时间内吸光度谱变化不大，但在第8天观察到动态降解效应。载铁蛋白研究揭示了260 nm附近吸光度的增长，这显示了渐进的和部分充满铁离子的蛋白质。图形抽象

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In vivo toxicity and biodegradation studies in mimicked biological media of bare and functionalised haematite nanoparticles

ABSTRACT Bare and functionalised haematite nanoparticles (NPs) are synthesised through the co-precipitation method and characterised using XRD, SEM, TEM, EDX, FTIR, and VSM. XRD confirmed the rhombohedral-based hexagonal structure of Fe2O3, while, TEM and SEM showed the formation of lamellar-shaped NPs with the grain size varied from 22 to 80 nm. VSM presented soft ferromagnetic behaviour. From in vivo evaluations, changes in serum levels are analysed at different days of study after administration of bare and coated NPs through the intraperitoneal route of administration in albino rats. Toxicity parameters revealed a transient increase at day 1 but a gradual decrease thereafter. For biodegradation studies, NPs exposure in lysosomal-like medium showed insignificant changes in the absorbance spectrum for a short interval of time, however, dynamical degradation effects were observed on Day 8. Apoferritin studies disclose the growth of absorbance near 260 nm, which reveals progressive and partially filled proteins with iron ions. GRAPHICAL ABSTRACT

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来源期刊

Advances in Applied Ceramics 工程技术-材料科学：硅酸盐

CiteScore

4.40

自引率

4.50%

发文量

审稿时长

5.2 months

期刊介绍： Advances in Applied Ceramics: Structural, Functional and Bioceramics provides international coverage of high-quality research on functional ceramics, engineering ceramics and bioceramics.