A. Tiwari, N. Agrawal, M. Thakur, G. Nagendrappa, A. Thakur
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Modelling of Anti-HIV-1 Activity of Piperidine-4-carboxamide CCR5 Antagonist: Role of Structural Manipulation
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(3).3006-3010 ABSTRACT: Present study is aimed to understand the role of structural manipulation in modeling of anti-HIV-1 activity of Piperidine-4-Carboxamide CCR5 antagonists. For the purpose a set of 21 Piperidine-4-Carboxamide has been chosen. Study explores the role of various, structural features like size, substitution and steric properties in anti-HIV1 activity of Piperidine-4-Carboxamide CCR5 antagonists derivatives. Multiple regression method is adopted to understand the role of structural manipulation in modeling the logIC50 activity. Statistics generated from the study shows that none of the parameter having statistical significant value of r but bi-parametric to tetra-parametric combinations produced the improved regression value.
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