HEMATOLOGICAL STATUS OF SIMMENTAL BREDINSKY MEAT TYPE HEIFERS WITH DIFFERENT ALLELIC SET OF CAPN1 AND TG5 GENES

The work carried out by geneticists in recent years connected with whole genome genotyping of cattle by SNP polymorphism with identification of associations with qualitative and quantitative parameters of productivity is used in innovative breeding programs. However, biochemical mechanisms of such determinations are not fully disclosed. Expression of polymorphic genes, which leads to a change of protein properties, is associated with biochemical processes which occur in the animal body at biomolecular level, which can manifest itself in neurohumoral and metabolic processes, which can possibly be traced by analyzing blood parameters. In this regard, blood was taken from the heifers of Bredinsky meat type of Simmental breed in Chelyabinsk region in order to isolate DNA to determine polymorphism of CAPN1 and TG5 genes associated with qualitative parameters of meat productivity and determine hematological parameters. The analysis of the genotyped population revealed a certain alignment of polymorphic state of the genes of the animals of the studied sample. The distribution of hematological parameters of heifers according to the genotypes of the studied genes did not show a clear significant difference, but outlined some tendencies. According to morphological composition of the blood, these tendencies were less expressed. However, the distribution of blood biochemical parameters by genotypes of CAPN1 gene showed superiority of GG genotype by blood glucose by 0.51 mmol / l, which is 21.9%, the content of ALT transamination enzymes by 11.9%, cholesterol by 18.8% . Difference tendencies were noted for genotypes of TG5 gene by creatinine (12.0%) and amylase (9.5%) content. The results of this study may be useful in terms of accumulating new research data and contribute to a better understanding of molecular mechanisms of relations among blood parameters, genes, and biochemical processes in animals.