以苯基钛试剂为亲核试剂合成二芳基甲烷的新方法

Journal of Chemical Research-s Pub Date : 2022-03-01 DOI:10.1177/17475198221091941

He Zhang

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引用次数: 1

摘要

介绍了钯催化的各种取代苯钛与三氟化芳基酯的交叉偶联反应，通过高选择性的C-O键功能化，以高达94%的收率合成二芳基甲烷。苯基钛作为亲核试剂，在较短的反应时间内实现了C(sp2) -C (sp3)的高效交叉偶联。反应在60℃下进行，并表现出良好的官能团耐受性。

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A new protocol for synthesizing diarylmethanes using a benzyltitanium reagent as a nucleophile

The first palladium-catalyzed cross-coupling of various substituted benzyltitaniums with aryl triflates is presented for the synthesis of diarylmethanes in yields of up to 94% through highly selective C–O bond functionalization. The benzyltitaniums act as nucleophiles to realize the C(sp2)–C(sp3) cross-coupling with high efficiency in short reaction times. The reactions proceed at 60°C and show excellent functional groups tolerance.

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来源期刊

Journal of Chemical Research-s 化学科学, 有机化学, 有机合成

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Chemical Research is a peer reviewed journal that publishes full-length review and research papers in all branches of experimental chemistry. The journal fills a niche by also publishing short papers, a format which favours particular types of work, e.g. the scope of new reagents or methodology, and the elucidation of the structure of novel compounds. Though welcome, short papers should not result in fragmentation of publication, they should describe a completed piece of work. The Journal is not intended as a vehicle for preliminary publications. The work must meet all the normal criteria for acceptance as regards scientific standards. Papers that contain extensive biological results or material relating to other areas of science may be diverted to more appropriate specialist journals. Areas of coverage include: Organic Chemistry; Inorganic Chemistry; Materials Chemistry; Crystallography; Computational Chemistry.