2019年埃塞俄比亚西北部所有入院的先天性和先天性新生儿病例档案中与新生儿高胆红素血症相关的因素

M. Bogale, Worknesh Akanaw Bogale, D. Kassie, Abebe Woldesellassie, Animut Tagele Tamiru
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引用次数: 1

摘要

背景:黄疸是由高胆红素血症引起的皮肤和眼睛的黄色变色。黄疸通常在2至3mg /dL水平时出现在巩膜上。全世界每年约有110万新生儿患上高胆红素血症,其中绝大多数生活在撒哈拉以南非洲和南亚。据估计,2016年,全世界每10万例活产中约有8例5岁以下儿童死于新生儿黄疸。本研究旨在评估埃塞俄比亚贡达尔大学综合专科医院所有先天性和先天性新生儿中高胆红素血症的患病率及相关因素。方法:对2017年3月至2019年3月在贡达尔大学综合专科医院住院的所有出生和出生新生儿399例病例进行回顾性横断面研究。提取的数据输入Epi Info软件(7.0版本),使用SPSS软件(21.0版本)导出并分析。将双变量分析中p值小于0.2的变量纳入最终模型,并以小于0.05声明统计学显著性。影响新生儿高胆红素血症结果的大小和统计学相关因素是本研究的主要结局指标。结果:总体而言,31.6% (n=126)的入院新生儿出现高胆红素血症。产妇和新生儿RH不相容、ABO不相容、低出生体重、低血糖和出生创伤是与新生儿高胆红素血症相关的主要统计学意义因素。结论:与埃塞俄比亚部分地区其他关于新生儿高胆红素血症的研究报告相比,本研究中新生儿高胆红素血症的患病率较高。导致新生儿高胆红素血症的主要因素是RH不相容、低出生体重、出生创伤和低血糖。因此,通过早期预防和及时治疗新生儿高胆红素血症,预防或减少与此病相关的短期和长期并发症是很重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors Associated with Neonatal Hyperbilirubinemia in Case Files of All Admitted Inborn and Outborn Neonates in Northwest Ethiopia in 2019
Background: Jaundice is a yellow discoloration of the skin and eyes caused by hyperbilirubinemia. Jaundice usually becomes visible on the sclera at a level of 2 to 3 mg/dL. Each year, about 1.1 million neonates develop hyperbilirubinemia in the world the vast majority of whom live in sub-Saharan Africa and South Asia. In 2016, neonatal jaundice was estimated to account for about 8 under-5 mortalities per 100,000 live births worldwide. This study aimed to assess the prevalence and associated factors of hyperbilirubinemia among all the inborn and outborn neonates at University of Gondar Comprehensive Specialized Hospital in Gondar, Ethiopia. Methods: The current institutional-based retrospective cross-sectional study was conducted on 399 case files of all the admitted inborn and outborn neonates at University of Gondar Comprehensive Specialized Hospital within March 2017 to March 2019. The extracted data were entered into Epi Info software (version 7.0) and exported and analyzed using SPSS software (version 21.0). Variables with a p-value of less than 0.2 in the bivariate analysis were included in the final model, and the statistical significance was declared at less than 0.05. Both the size and statistically associated factors affecting the results of neonatal hyperbilirubinemia were the main outcome measures in this study. Results: Overall, 31.6% (n=126) of the admitted neonates developed hyperbilirubinemia. Maternal and neonatal Rhesus (RH) incompatibility, ABO incompatibility, low birth weight, hypoglycemia, and birth trauma were the main statistically significant factors associated with neonatal hyperbilirubinemia. Conclusion: The prevalence of neonatal hyperbilirubinemia in this study was high in comparison to that reported for other studies carried out on neonatal hyperbilirubinemia in some parts of Ethiopia. The major factors causing hyperbilirubinemia in neonates were RH incompatibility, low birth weight, birth trauma, and hypoglycemia. Therefore, by the early prevention and prompt treatment of hyperbilirubinemia in neonates, it is important to prevent or reduce both short-term and long-term complications related to this condition.
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