气相色谱联用质谱联用火焰电离检测器分析巴基斯坦狂欢毒品氯胺酮:个案研究

Q4 Social Sciences
Tahir Jamshaid, Muhammad Usman, Muhammad Shahwar, Abid Naseer, Muhammad Taimoor Chaudhary, M. Sarwar, M. A. Tahir
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引用次数: 0

摘要

氯胺酮是一种芳基环烷基胺,被归类为环烷,与苯环利定(PCP)有化学关系。氯胺酮可以用改良的斯科特试验和碱性溴化金试验鉴别。本案例研究涉及氯胺酮样本的分析。采用化学斑点试验、FT-IR和GC-MS对样品进行定性分析,无衍生化。此外,建立并验证了一种气相色谱火焰电离检测器(FID)定量分析氯胺酮的方法。以氯胺酮在10 ~ 100μg/mL范围内为标准参比标准,建立线性相关关系,回归系数R2 = 0.9997。该方法产样率为90.27%。上述技术和方法提供了可比较的定性和定量分析结果,有助于执法机构和法医学界利用气相色谱联用FID对氯胺酮进行筛选和定量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Ketamine, a Rave Drug in Pakistan, using Gas Chromatography Coupled with Mass Spectrometer and Flame Ionization Detector: A Case Study
Ketamine is an arylcycloalkylamine, classified as cyclidine and chemically related to phencyclidine (PCP). Ketamine can be identified using modified Scott’s Test and Alkaline Gold Bromide test. This case study involved the analysis of a Ketamine sample. The sample was analyzed qualitatively by chemical spot tests, FT-IR and GC-MS without derivatization. Furthermore, a developed and validated method was used for the quantitative analysis of Ketamine using Gas Chromatography with a Flame Ionization Detector (FID). The certified reference standard of Ketamine in the range of 10- 100μg/mL was used for developing linear correlation with regression coefficient (R2 = 0.9997) for the method. The method produced percentage of sample as 90.27%. The above mentioned techniques and methods provide comparable qualitative and quantitative analytical results helping law enforcement agencies and the forensic community in screening and quantification of ketamine using GCMS coupled with FID.
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来源期刊
CiteScore
0.30
自引率
0.00%
发文量
8
审稿时长
12 weeks
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