Preventive differentiated therapy of exogenous-constitutional obesity recurrence in females

The purpose — to develop a method for preventive differentiated therapy of exogenous-constitutional obesity recurrence in females based on monitoring of psychophysiological reactivity and neurohumoral regulation. Material and methods. 241 females with exogenous-constitutional obesity and 45 healthy females were examined. The patients of the main (123 persons) and control (118 persons) groups were under observation during 8 months. The body mass index, the leptin hormone level, and the duration of blink reflex were assessed on monitoring. Reflexotherapy, diet therapy and physiotherapy were applied in the main group. Statistical processing was performed by nonparametric methods. Results. Variants of developing obesity recurrence were determined: 1) with primary change of psychophysiological reactivity; 2) with primary change of neurohumoral regulation. In the first variant, reflexotherapy was prescribed, and in the second — hypocaloric diet and physiotherapy. The obesity recurrence in the control group was registered in 85.6% of all observations, and in the main group — in 14.6% of observations (p < 0.01). Conclusions. The proposed method of preventive differentiated therapy based on monitoring of psychophysiological reactivity and neurohumoral regulation allowed decreasing the recurrence rate in females with exogenous-constitutional obesity.