肝脏间隙连接的结构、调节和功能

Q2 Biochemistry, Genetics and Molecular Biology

Cell Communication and Adhesion Pub Date : 2015-11-02 DOI:10.3109/15419061.2016.1151875

Joost Willebrords, Sara Crespo Yanguas, M. Maes, E. Decrock, Nan Wang, L. Leybaert, T. C. da Silva, Isabel Veloso Alves Pereira, H. Jaeschke, B. Cogliati, M. Vinken

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引用次数: 19

摘要

间隙连接是一组特殊的细胞间连接，介导细胞间的直接通讯。它们产生于相邻细胞的两个半通道的相互作用，而这两个半通道又由六种连接蛋白组成。在肝脏中，间隙连接主要存在于肝细胞中，并在肝脏生命周期的几乎所有阶段发挥关键作用，包括细胞生长、分化、肝脏特异性功能和细胞死亡。肝间隙连接通过多种机制进行调控，从连接蛋白表达的表观遗传控制到间隙连接活性的翻译后调控。本文综述了关于肝间隙连接的结构、控制和功能相关性的现有和新的方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Structure, Regulation and Function of Gap Junctions in Liver

Abstract Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular communication between cells. They arise from the interaction of two hemichannels of adjacent cells, which in turn are composed of six connexin proteins. In liver, gap junctions are predominantly found in hepatocytes and play critical roles in virtually all phases of the hepatic life cycle, including cell growth, differentiation, liver-specific functionality and cell death. Liver gap junctions are directed through a broad variety of mechanisms ranging from epigenetic control of connexin expression to post-translational regulation of gap junction activity. This paper reviews established and novel aspects regarding the architecture, control and functional relevance of liver gap junctions.

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来源期刊

Cell Communication and Adhesion 生物-生化与分子生物学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cessation Cell Communication and Adhesion is an international Open Access journal which provides a central forum for research on mechanisms underlying cellular signalling and adhesion. The journal provides a single source of information concerning all forms of cellular communication, cell junctions, adhesion molecules and families of receptors from diverse biological systems. The journal welcomes submission of original research articles, reviews, short communications and conference reports.