内皮抑素和骨桥蛋白在冠状动脉疾病和主动脉瓣钙化患者中均升高

Michael Sponder , Monika Fritzer-Szekeres , Brigitte Litschauer , Thomas Binder , Jeanette Strametz-Juranek
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引用次数: 7

摘要

血管抑制因子内皮抑素(ES)在血管生成中起着重要的中介作用。骨桥蛋白(OPN)升高与健康人瓣膜钙化有关。本研究旨在探讨冠状动脉疾病(CAD)和主动脉瓣钙化(AVC)患者ES和OPN水平。方法和结果224例非或戒烟患者(男性161例,平均年龄:61.09±11.02岁;女性63例,平均年龄67.49±7.87岁,经血管造影证实并量化冠心病。ELISA检测血清ES和血浆OPN水平,胸骨旁短轴观察AVC,并将AVC量化为非、轻度或中/重度。ES随AVC严重程度的增加而逐渐增加,与年龄、BMI和cad严重程度无关(p = 0.018;f = 4.09)。OPN也随AVC严重程度的不同而显著增加(p = 0.029;F = 3.61),但当协变量(p = 0.31;F = 1.18)。结论:这是首个显示冠心病患者ES与AVC之间存在独立于年龄、BMI和冠心病严重程度的关联的研究,在试图了解心脏瓣膜钙化过程时,这似乎具有独特的意义。OPN也与avc严重程度相关,但主要取决于患者的年龄。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endostatin and osteopontin are elevated in patients with both coronary artery disease and aortic valve calcification

Background

The angiostatic factor endostatin (ES) plays an important role as mediator of angiogenesis. Elevated osteopontin (OPN) was associated with valve calcification in healthy individuals. The present study aimed to investigate ES and OPN levels in patients with both coronary artery disease (CAD) and aortic valve calcification (AVC).

Methods and results

In total 224 non- or ex-smoking patients (161 male, mean age: 61.09 ± 11.02 years; 63 female: mean age: 67.49 ± 7.87 years) with angiographically verified and quantified CAD were recruited. Serum ES and plasma OPN levels were measured by ELISA and AVC was evaluated by a parasternal short axis view and quantified as non-, mild or moderate/severe. There was a stepwise increase of ES measurable with increasing severity of AVC, independent from age, BMI and CAD-severity (p = 0.018; F = 4.09). OPN also increased significantly with the grade of AVC severity (p = 0.029; F = 3.61) but was no longer significant when the co-variables (p = 0.31; F = 1.18) were inserted.

Conclusions

This is the first study showing an association of ES with AVC in CAD-patients independent from age, BMI and CAD-severity which seems to be of distinct interest when trying to understand the process of heart valve calcification. OPN also correlates with AVC-severity but is mostly dependent on the age of the patients.

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