FORMULATION AND EVALUATION OF HYDRODYNAMICALLY BALANCED FLOATING TABLETS OF GLYCYRRHIZA GLABRA EXTRACT

The aim of the study is to formulate, optimize and evaluate Glycyrrhiza glabra floating tablets using 23 optimization technique for the treatment of asthma. The extract of Glycyrrhiza glabra was prepared by subjecting crude drug to hot continuous percolation method using Soxhlet apparatus using distilled water and ethanol. The floating matrix tablets of Glycyrrhiza glabra was prepared by wet granulation technique using extract of Glycyrrhiza glabra, HPMC K15M as polymer, starch/honey as binder and sodium bicarbonate & citric acid as effervescent agents by 23 factorial design. The independent variables are polymer (X1), concentrations of effervescence agents (X2) and binders used for granulation (X3). The dependent variables are hardness (Y1), buoyancy lag time (Y2), total floating time (Y3), and in-vitro drug release (Y4). The compatibility studies showed that there is no chemical interaction between the drug, polymer and the excipients used in the tablets. The prepared floating tablets were subjected to all post compression parameters such as hardness, friability, swelling capacity, buoyancy, total floating time, drug content &in-vitro drug release and were found to be within normal limits. Based on drug content, buoyancy lag time and in-vitro drug release the formulations F8 was found to be the promising system for anti-asthmatic therapy. The present study reports for the development of gastric floating tablet for Glycyrrhiza glabra following oral administration.