脱烯官能化：通过基于氧化还原的自由基过程将烯的 C(sp3)-C(sp2) 键转化为 C(sp3)-X 键。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2024-01-01 Epub Date: 2023-04-12 DOI:10.1055/a-2044-4571

Brady W Dehnert, Jeremy H Dworkin, Ohyun Kwon

引用次数: 0

摘要

本综述重点介绍脱烯官能化的历史和最新进展。通过这种解构策略，可在温和、稳健的条件下进行自由基官能化。所述反应具有高效率和良好的立体选择性，可容忍多种官能团，并可在几分钟内完成。通过裂解萜类和萜类衍生前体的 C(sp3)-C(sp2) 键，可以快速实现天然产品的多样化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dealkenylative Functionalizations: Conversion of Alkene C(sp³)-C(sp²) Bonds into C(sp³)-X Bonds via Redox-Based Radical Processes.

This review highlights the history and recent advances in dealkenylative functionalization. Through this deconstructive strategy, radical functionalizations occur under mild, robust conditions. The reactions described proceed with high efficiency, good stereoselectivity, tolerate many functional groups, and are completed within a matter of minutes. By cleaving the C(sp³)-C(sp²) bond of terpenes and terpenoid-derived precursors, rapid diversification of natural products is possible.

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.