{"title":"慢性自发性荨麻疹患者疾病活动性与凝血级联标志物的相关性:一项基于医院的横断面研究","authors":"Ayesha Sharmeen, M. Adil, Ravi Kumar","doi":"10.18203/issn.2455-4529.intjresdermatol20232538","DOIUrl":null,"url":null,"abstract":"Background: Both extrinsic as well as intrinsic coagulation cascade are involved in the pathogenesis of Chronic spontaneous urticaria. This study was done to correlate the disease activity and markers of coagulation cascade in patients of CSU.\nMethods: A hospital-based, cross-sectional, descriptive study was carried out in 100 patients of chronic urticaria. Baseline D-Dimer, prothrombin time, activated partial thromboplastin time was performed. Disease activity was assessed using Urticaria activity score over 7 days.\nResults: Of total 100 patients, d-dimer was raised in 72 (72%) patients. Correlation between D-dimer and UAS-7 days showed significant covariance between D-dimer and UAS-7 (p<0.001, r=0.93). Prothrombin time was raised in 55 (55%) patients. Significant correlation was found between PT and UAS-7 (p<0.001, r=0.76). Raised APTT was observed in 61(61%) patients. Correlation between APTT and UAS-7 showed that there was a significant covariance between APTT and UAS-7 (p<0.001, r=0.59).\nConclusions: A significant correlation between markers of coagulation cascade and the disease activity in patients of CSU was seen. These markers can help predict the disease severity and possibly monitor therapeutic response.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"2 11 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation between disease activity and markers of coagulation cascade in patients of chronic spontaneous urticaria: a hospital based cross-sectional study\",\"authors\":\"Ayesha Sharmeen, M. Adil, Ravi Kumar\",\"doi\":\"10.18203/issn.2455-4529.intjresdermatol20232538\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Both extrinsic as well as intrinsic coagulation cascade are involved in the pathogenesis of Chronic spontaneous urticaria. This study was done to correlate the disease activity and markers of coagulation cascade in patients of CSU.\\nMethods: A hospital-based, cross-sectional, descriptive study was carried out in 100 patients of chronic urticaria. Baseline D-Dimer, prothrombin time, activated partial thromboplastin time was performed. Disease activity was assessed using Urticaria activity score over 7 days.\\nResults: Of total 100 patients, d-dimer was raised in 72 (72%) patients. Correlation between D-dimer and UAS-7 days showed significant covariance between D-dimer and UAS-7 (p<0.001, r=0.93). Prothrombin time was raised in 55 (55%) patients. Significant correlation was found between PT and UAS-7 (p<0.001, r=0.76). Raised APTT was observed in 61(61%) patients. Correlation between APTT and UAS-7 showed that there was a significant covariance between APTT and UAS-7 (p<0.001, r=0.59).\\nConclusions: A significant correlation between markers of coagulation cascade and the disease activity in patients of CSU was seen. These markers can help predict the disease severity and possibly monitor therapeutic response.\",\"PeriodicalId\":14331,\"journal\":{\"name\":\"International Journal of Research in Dermatology\",\"volume\":\"2 11 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Research in Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232538\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Research in Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232538","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Correlation between disease activity and markers of coagulation cascade in patients of chronic spontaneous urticaria: a hospital based cross-sectional study
Background: Both extrinsic as well as intrinsic coagulation cascade are involved in the pathogenesis of Chronic spontaneous urticaria. This study was done to correlate the disease activity and markers of coagulation cascade in patients of CSU.
Methods: A hospital-based, cross-sectional, descriptive study was carried out in 100 patients of chronic urticaria. Baseline D-Dimer, prothrombin time, activated partial thromboplastin time was performed. Disease activity was assessed using Urticaria activity score over 7 days.
Results: Of total 100 patients, d-dimer was raised in 72 (72%) patients. Correlation between D-dimer and UAS-7 days showed significant covariance between D-dimer and UAS-7 (p<0.001, r=0.93). Prothrombin time was raised in 55 (55%) patients. Significant correlation was found between PT and UAS-7 (p<0.001, r=0.76). Raised APTT was observed in 61(61%) patients. Correlation between APTT and UAS-7 showed that there was a significant covariance between APTT and UAS-7 (p<0.001, r=0.59).
Conclusions: A significant correlation between markers of coagulation cascade and the disease activity in patients of CSU was seen. These markers can help predict the disease severity and possibly monitor therapeutic response.