{"title":"重构心肌的生化和结构成像","authors":"Choukri Mekkaoui , David E Sosnovik","doi":"10.1016/j.cophys.2022.100570","DOIUrl":null,"url":null,"abstract":"<div><p>Remodeling of the myocardium results in changes in the molecular, cellular, and microstructural properties of the heart. Traditionally, these changes have been characterized using microscopy of tissue specimens taken from the heart. However, recent advances in biomedical imaging now make it possible to characterize many of these processes noninvasively. In this review, we focus on key principles and recent advances in molecular, cellular, and microstructural imaging of the heart after ischemic injury. Techniques to image cardiomyocyte death, inflammation, fibrosis, and microstructural remodeling of the heart are highlighted.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"28 ","pages":"Article 100570"},"PeriodicalIF":2.5000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biochemical and structural imaging of remodeled myocardium\",\"authors\":\"Choukri Mekkaoui , David E Sosnovik\",\"doi\":\"10.1016/j.cophys.2022.100570\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Remodeling of the myocardium results in changes in the molecular, cellular, and microstructural properties of the heart. Traditionally, these changes have been characterized using microscopy of tissue specimens taken from the heart. However, recent advances in biomedical imaging now make it possible to characterize many of these processes noninvasively. In this review, we focus on key principles and recent advances in molecular, cellular, and microstructural imaging of the heart after ischemic injury. Techniques to image cardiomyocyte death, inflammation, fibrosis, and microstructural remodeling of the heart are highlighted.</p></div>\",\"PeriodicalId\":52156,\"journal\":{\"name\":\"Current Opinion in Physiology\",\"volume\":\"28 \",\"pages\":\"Article 100570\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2022-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468867322000888\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867322000888","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Biochemical and structural imaging of remodeled myocardium
Remodeling of the myocardium results in changes in the molecular, cellular, and microstructural properties of the heart. Traditionally, these changes have been characterized using microscopy of tissue specimens taken from the heart. However, recent advances in biomedical imaging now make it possible to characterize many of these processes noninvasively. In this review, we focus on key principles and recent advances in molecular, cellular, and microstructural imaging of the heart after ischemic injury. Techniques to image cardiomyocyte death, inflammation, fibrosis, and microstructural remodeling of the heart are highlighted.
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