一次食物沙门氏菌病暴发的临床流行病学和实验室特征

I. Nikolaeva, S. V. Tkacheva, A. I. Fazulzyanova, E. Z. Latfullina, O. A. Rakhmanova, M. N. Belova
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引用次数: 0

摘要

在细菌性肠道感染中,沙门氏菌病占主要地位之一。目的探讨一起食品暴发沙门氏菌病的临床、流行病学和实验室特征。材料和方法。对2021年9月喀山共和国临床传染病医院发生的一起食物暴发沙门氏菌病患者的29份病历进行回顾性分析。结果。沙门氏菌病可能的传播因素是荷包蛋和/或淡盐鲑鱼。患者中以年轻女性为主(83%)。根据中度(96.6%)的胃肠道变异(69%)进行疾病,结果良好(100%)。结肠炎综合征的发生率为31%。在生化参数中,高CRP (161.97 (108.54) mg/l)引起了注意,达到了严重细菌感染的特征值。在粪便和/或呕吐物细菌学检查中,所有患者均分离出肠炎沙门氏菌。肠炎沙门氏菌对氨苄西林、头孢吡肟、头孢曲松、氯霉素、沙门氏菌噬菌体敏感,对培氟沙星和复方新诺明的耐药率分别为80%和40%。结论。在病因不同类型腹泻的鉴别诊断初期,CRP持续升高可用于决定感染性腹泻患者的治疗策略。为了最大限度地提高沙门氏菌病抗菌治疗的有效性,有必要关注区域抗生素敏感性概况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical-epidemiological and laboratory characteristics of a food salmonellosis outbreak
Among bacterial intestinal infections, salmonellosis occupies one of the leading places. The purpose to study the clinical, epidemiological and laboratory features of a food outbreak of salmonellosis. Material and methods. A retrospective analysis of 29 medical records of patients from a food outbreak of salmonellosis hospitalized in the Republican Clinical Infectious Diseases Hospital of Kazan in September 2021. Results. The likely transmission factors for Salmonellosis were poached egg and/or lightly salted salmon. Young females predominated (83%) among patients. The disease proceeded according to the gastroenteric variant (69%) of moderate severity (96.6%) with a favorable outcome (100%). The incidence of colitis syndrome was 31%. Among the biochemical parameters, high levels of CRP (161.97 (108.54) mg/l) attracted attention, reaching values characteristic of a severe bacterial infection. In bacteriological examination of faeces and/or vomit, Salmonella enteritidis was isolated from all patients. The isolated strains of S. enteritidis were sensitive to ampicillin, cefepime, ceftriaxone, chloramphenicol, salmonella bacteriophage, 80% of the isolates were resistant to pefloxacin and 40% to co-trimoxazole. Conclusions. A persistent increase in CRP can be used at the initial stage of differential diagnosis of etiologically different types of diarrheas to decide on the tactics of treating patients with infectious diarrhea. In order to maximize the effectiveness of antimicrobial treatment of salmonellosis, it is necessary to focus on regional antibiotic susceptibility profiles.
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