体外和体内肿瘤模型在热疗效应研究中的应用综述

Zahra Zahedi-Tabar, S. Bagheri‐Khoulenjani, S. Amanpour, H. Mirzadeh
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引用次数: 5

摘要

热疗是一种治疗癌症的新方法。为了在热疗中加热组织时获得最佳控制,建议使用磁性纳米颗粒。局部热控制在该技术中非常重要,以防止肿瘤周围健康组织的损伤,因此有必要测量温度的变化,以确定热疗可以产生预期结果的最佳条件。在整个热疗过程中,纳米颗粒的类型和浓度以及纳米颗粒在癌组织内的分布是影响温度分布的关键因素。影响纳米颗粒分布的主要因素之一是扩散介质的特性,如化学成分、形态和力学特征,这些都影响纳米颗粒在肿瘤部位的扩散。本文综述了最常见的体外和体内介质及其对热疗结果的影响。我们也提到了计算机模型。缓冲液、细胞培养物、微液、死亡组织和动物模型是本文讨论的一些体外培养基。此外,还将提到一些用于热疗的动物模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review on the Application of In Vitro and In Vivo Models of Cancerous Tumors for the Study of the Hyperthermia Effect
Hyperthermia is a novel method for cancer therapy. To have the best control when heating tissues in hyperthermia, the use of magnetic nanoparticles is suggested. The local control of heat is very important in this technique, to prevent the damage of healthy tissues around the tumor, and therefore it is necessary to measure changes in temperature to determine the optimum conditions in which hyperthermia can create the desired results. The type and concentration of nanoparticles and nanoparticle distribution within the cancerous tissue are key factors affecting temperature distribution throughout the hyperthermia process. One of the main factors influencing nanoparticle distribution is the characteristics of the diffusion media, such as chemical composition, morphological and mechanical features, all of which affect the diffusion of nanoparticles at the cancer site. In this review, the most common in vitro and in vivo media and their influence on the results of hyperthermia are discussed. We also mention in silico as a computational model. Buffer solutions, cell cultures, microfluids, dead tissues and animal models are some of the in vitro media that are discussed in this review paper. In addition, some of the animal models used for hyperthermia will be mentioned.
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