槲皮素和二氢槲皮素对大鼠肝脏线粒体某些功能参数的影响

U. Gayibov, Sabina Gayibova, M. Pozilov, Feruza Sh. Tuxtaeva, U. R. Yusupova, Gulchehra M.-K. Djabbarova, Zulayho A. Mamatova, N. Ergashev, T. Aripov
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引用次数: 3

摘要

黄酮类化合物是一种重要的植物源性化合物,普遍存在于富含水果和蔬菜的饮食中,具有自由基猝灭能力。槲皮素作为黄酮亚类黄酮醇的一员,因其巨大的潜力而受到广泛关注。槲皮素被证明通过抑制脂质过氧化来保护多种退行性疾病。本文研究了槲皮素和二氢槲皮素这两种多酚类化合物对线粒体功能参数的影响。因此,上述黄酮醇具有线粒体通透性过渡孔(mPTP)抑制和atp敏感的钾通道激活能力,以及较强的抗氧化/抗辐射活性。槲皮素和二氢槲皮素对线粒体功能参数的改善为所研究的黄酮醇可能具有抗缺氧防御作用的假设提供了基本思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
INFLUENCE OF QUERCETIN AND DIHYDROQUERCETIN ON SOME FUNCTIONAL PARAMETERS OF RAT LIVER MITOCHONDRIA
Flavonoids are proved to be prominent plant-derived compounds generally found in fruit- and vegetable- rich diets with free radicals quenching ability. Quercetin, a member of flavonoids subclass – flavonols, has gained major attention due to its overwhelming potential. Quercetin was demonstrated to preserve diverse degenerative diseases by inhibiting lipid peroxidation. In the present paper, we deal with two polyphenolic compounds’ – quercetin and dihydroquercetin – influence on functional parameters of mitochondria. Thus, the fore mentioned flavonols showed the mitochondrial permeability transition pore (mPTP) inhibition and ATP-sensitive potassium channel activation capacities as well as strong antioxidаnt/antiradiсal activity. Improving functional parameters of mitochondria by both quercetin and dihydroquercetin formed a basic idea of the hypothesis that the studied flavonols may provide antihypoxic defense.
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