Annalie Shears, Georgina Yan, Harriet Mortimer, Elizabeth Cross, Shari Sapuan, Seilesh Kadambari, Suzanne Luck, Paul T Heath, Simone Walter, Katy J Fidler
{"title":"先天性巨细胞病毒感染儿童的前庭和平衡功能障碍：系统综述。","authors":"Annalie Shears, Georgina Yan, Harriet Mortimer, Elizabeth Cross, Shari Sapuan, Seilesh Kadambari, Suzanne Luck, Paul T Heath, Simone Walter, Katy J Fidler","doi":"10.1136/archdischild-2021-323380","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This systematic review evaluates vestibular and balance dysfunction in children with congenital cytomegalovirus (cCMV), makes recommendations for clinical practice and informs future research priorities.</p><p><strong>Design: </strong>MEDLINE, Embase, EMCARE, BMJ Best Practice, Cochrane Library, DynaMed Plus and UpToDate were searched from inception to 20 March 2021 and graded according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.</p><p><strong>Patients: </strong>Children with cCMV diagnosed within 3 weeks of life from either blood, saliva and/or urine (using either PCR or culture).</p><p><strong>Intervention: </strong>Studies of vestibular function and/or balance assessments.</p><p><strong>Main outcome measures: </strong>Vestibular function and balance.</p><p><strong>Results: </strong>1371 studies were identified, and subsequently 16 observational studies were eligible for analysis, leading to an overall cohort of 600 children with cCMV. All studies were of low/moderate quality. In 12/16 studies, vestibular function tests were performed. 10/12 reported vestibular dysfunction in ≥40% of children with cCMV. Three studies compared outcomes for children with symptomatic or asymptomatic cCMV at birth; vestibular dysfunction was more frequently reported in children with symptomatic (22%-60%), than asymptomatic cCMV (0%-12.5%). Two studies found that vestibular function deteriorated over time: one in children (mean age 7.2 months) over 10 months and the other (mean age 34.7 months) over 26 months.</p><p><strong>Conclusions: </strong>Vestibular dysfunction is found in children with symptomatic and asymptomatic cCMV and in those with and without hearing loss. Audiovestibular assessments should be performed as part of neurodevelopmental follow-up in children with cCMV. Case-controlled longitudinal studies are required to more precisely characterise vestibular dysfunction and help determine the efficacy of early supportive interventions.</p><p><strong>Prospero registration: </strong>CRD42019131656.</p>","PeriodicalId":51376,"journal":{"name":"European Journal of Personality","volume":"7 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606507/pdf/","citationCount":"0","resultStr":"{\"title\":\"Vestibular and balance dysfunction in children with congenital CMV: a systematic review.\",\"authors\":\"Annalie Shears, Georgina Yan, Harriet Mortimer, Elizabeth Cross, Shari Sapuan, Seilesh Kadambari, Suzanne Luck, Paul T Heath, Simone Walter, Katy J Fidler\",\"doi\":\"10.1136/archdischild-2021-323380\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This systematic review evaluates vestibular and balance dysfunction in children with congenital cytomegalovirus (cCMV), makes recommendations for clinical practice and informs future research priorities.</p><p><strong>Design: </strong>MEDLINE, Embase, EMCARE, BMJ Best Practice, Cochrane Library, DynaMed Plus and UpToDate were searched from inception to 20 March 2021 and graded according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.</p><p><strong>Patients: </strong>Children with cCMV diagnosed within 3 weeks of life from either blood, saliva and/or urine (using either PCR or culture).</p><p><strong>Intervention: </strong>Studies of vestibular function and/or balance assessments.</p><p><strong>Main outcome measures: </strong>Vestibular function and balance.</p><p><strong>Results: </strong>1371 studies were identified, and subsequently 16 observational studies were eligible for analysis, leading to an overall cohort of 600 children with cCMV. All studies were of low/moderate quality. In 12/16 studies, vestibular function tests were performed. 10/12 reported vestibular dysfunction in ≥40% of children with cCMV. Three studies compared outcomes for children with symptomatic or asymptomatic cCMV at birth; vestibular dysfunction was more frequently reported in children with symptomatic (22%-60%), than asymptomatic cCMV (0%-12.5%). Two studies found that vestibular function deteriorated over time: one in children (mean age 7.2 months) over 10 months and the other (mean age 34.7 months) over 26 months.</p><p><strong>Conclusions: </strong>Vestibular dysfunction is found in children with symptomatic and asymptomatic cCMV and in those with and without hearing loss. Audiovestibular assessments should be performed as part of neurodevelopmental follow-up in children with cCMV. Case-controlled longitudinal studies are required to more precisely characterise vestibular dysfunction and help determine the efficacy of early supportive interventions.</p><p><strong>Prospero registration: </strong>CRD42019131656.</p>\",\"PeriodicalId\":51376,\"journal\":{\"name\":\"European Journal of Personality\",\"volume\":\"7 1\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2022-05-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606507/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Personality\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/archdischild-2021-323380\",\"RegionNum\":1,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY, SOCIAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Personality","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/archdischild-2021-323380","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, SOCIAL","Score":null,"Total":0}
Vestibular and balance dysfunction in children with congenital CMV: a systematic review.
Objective: This systematic review evaluates vestibular and balance dysfunction in children with congenital cytomegalovirus (cCMV), makes recommendations for clinical practice and informs future research priorities.
Design: MEDLINE, Embase, EMCARE, BMJ Best Practice, Cochrane Library, DynaMed Plus and UpToDate were searched from inception to 20 March 2021 and graded according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.
Patients: Children with cCMV diagnosed within 3 weeks of life from either blood, saliva and/or urine (using either PCR or culture).
Intervention: Studies of vestibular function and/or balance assessments.
Main outcome measures: Vestibular function and balance.
Results: 1371 studies were identified, and subsequently 16 observational studies were eligible for analysis, leading to an overall cohort of 600 children with cCMV. All studies were of low/moderate quality. In 12/16 studies, vestibular function tests were performed. 10/12 reported vestibular dysfunction in ≥40% of children with cCMV. Three studies compared outcomes for children with symptomatic or asymptomatic cCMV at birth; vestibular dysfunction was more frequently reported in children with symptomatic (22%-60%), than asymptomatic cCMV (0%-12.5%). Two studies found that vestibular function deteriorated over time: one in children (mean age 7.2 months) over 10 months and the other (mean age 34.7 months) over 26 months.
Conclusions: Vestibular dysfunction is found in children with symptomatic and asymptomatic cCMV and in those with and without hearing loss. Audiovestibular assessments should be performed as part of neurodevelopmental follow-up in children with cCMV. Case-controlled longitudinal studies are required to more precisely characterise vestibular dysfunction and help determine the efficacy of early supportive interventions.
期刊介绍：
It is intended that the journal reflects all areas of current personality psychology. The Journal emphasizes (1) human individuality as manifested in cognitive processes, emotional and motivational functioning, and their physiological and genetic underpinnings, and personal ways of interacting with the environment, (2) individual differences in personality structure and dynamics, (3) studies of intelligence and interindividual differences in cognitive functioning, and (4) development of personality differences as revealed by cross-sectional and longitudinal studies.
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