{"title":"Q TRAP™质谱技术用于蛋白质组学应用","authors":"James W. Hager","doi":"10.1016/S1741-8372(04)02421-1","DOIUrl":null,"url":null,"abstract":"<div><p><span>Mass spectrometry (MS) can play an important part in the characterization of protein posttranslational modifications. The specificity of triple-quadrupole scan modes combined with the sensitivity of the linear ion-trap operational modes in Q TRAP™ MS instruments presents new opportunities for automated investigation of posttranslational modifications in biological samples. The triple-quadrupole precursor ion and constant neutral loss scans are very powerful for identifying peptides that have been posttranslationally modified. In addition, the ion-trap product ion scans can provide valuable information for </span>amino acid sequence determination and sites of modification.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 2","pages":"Pages 31-36"},"PeriodicalIF":0.0000,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02421-1","citationCount":"6","resultStr":"{\"title\":\"Q TRAP™ mass spectrometer technology for proteomics applications\",\"authors\":\"James W. Hager\",\"doi\":\"10.1016/S1741-8372(04)02421-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Mass spectrometry (MS) can play an important part in the characterization of protein posttranslational modifications. The specificity of triple-quadrupole scan modes combined with the sensitivity of the linear ion-trap operational modes in Q TRAP™ MS instruments presents new opportunities for automated investigation of posttranslational modifications in biological samples. The triple-quadrupole precursor ion and constant neutral loss scans are very powerful for identifying peptides that have been posttranslationally modified. In addition, the ion-trap product ion scans can provide valuable information for </span>amino acid sequence determination and sites of modification.</p></div>\",\"PeriodicalId\":100382,\"journal\":{\"name\":\"Drug Discovery Today: TARGETS\",\"volume\":\"3 2\",\"pages\":\"Pages 31-36\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02421-1\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today: TARGETS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1741837204024211\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: TARGETS","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1741837204024211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Q TRAP™ mass spectrometer technology for proteomics applications
Mass spectrometry (MS) can play an important part in the characterization of protein posttranslational modifications. The specificity of triple-quadrupole scan modes combined with the sensitivity of the linear ion-trap operational modes in Q TRAP™ MS instruments presents new opportunities for automated investigation of posttranslational modifications in biological samples. The triple-quadrupole precursor ion and constant neutral loss scans are very powerful for identifying peptides that have been posttranslationally modified. In addition, the ion-trap product ion scans can provide valuable information for amino acid sequence determination and sites of modification.
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