{"title":"多发性硬化症患者ABCB1 C3435T基因多态性频率及其与临床参数的相关性","authors":"E. Balkan, N. Bilge","doi":"10.4172/2155-9562.1000479","DOIUrl":null,"url":null,"abstract":"Background: People with Multiple Sclerosis (MS) show varying responses to the same drugs, suggesting a genetic factor. In addition, certain ABCB1 gene polymorphisms have been associated with resistance to many drugs. In the era of individualized treatment, identifying possible genetic causes of drug non responsiveness in MS patients may enable the prediction of nonresponse before treatment. Research is needed to determine relationships between ABCB1 polymorphisms and patients’ clinical parameters and drug response in MS.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"68 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ABCB1 C3435T Gene Polymorphism Frequency and Correlation with Clinical Parameters in Multiple Sclerosis\",\"authors\":\"E. Balkan, N. Bilge\",\"doi\":\"10.4172/2155-9562.1000479\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: People with Multiple Sclerosis (MS) show varying responses to the same drugs, suggesting a genetic factor. In addition, certain ABCB1 gene polymorphisms have been associated with resistance to many drugs. In the era of individualized treatment, identifying possible genetic causes of drug non responsiveness in MS patients may enable the prediction of nonresponse before treatment. Research is needed to determine relationships between ABCB1 polymorphisms and patients’ clinical parameters and drug response in MS.\",\"PeriodicalId\":16455,\"journal\":{\"name\":\"Journal of Neurology and Neurophysiology\",\"volume\":\"68 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neurology and Neurophysiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2155-9562.1000479\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurology and Neurophysiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2155-9562.1000479","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ABCB1 C3435T Gene Polymorphism Frequency and Correlation with Clinical Parameters in Multiple Sclerosis
Background: People with Multiple Sclerosis (MS) show varying responses to the same drugs, suggesting a genetic factor. In addition, certain ABCB1 gene polymorphisms have been associated with resistance to many drugs. In the era of individualized treatment, identifying possible genetic causes of drug non responsiveness in MS patients may enable the prediction of nonresponse before treatment. Research is needed to determine relationships between ABCB1 polymorphisms and patients’ clinical parameters and drug response in MS.
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