辅酶Q10、核黄素、烟酸、硒和栓皮栎对实验性动脉粥样硬化心脏异常的保护作用

Umapathi Indumathi, Karvannan Kanchana, Panchanatham Sachdanandam
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引用次数: 4

摘要

动脉粥样硬化的特点是脂质在动脉壁沉积,炎症细胞如单核细胞和淋巴细胞浸润。高脂血症是动脉粥样硬化过早发展的主要危险因素,它已被证明会增加心肌缺血和心脏事件的发生率。本研究的目的是评估CoQ10、核黄素、烟酸、硒(CoRNS)和Emblica officinalis (Amla)对雄性wistar白化大鼠的降血脂和心脏保护作用,这些大鼠在高胆固醇饮食(HCD)的基础上添加4%的胆固醇和1%的胆酸,持续30天导致动脉粥样硬化。30 d后,IV组以辛伐他汀为标准药物治疗,V组以CoRNS和Amla治疗。所有药物均灌胃给药30 d。第三组动物作为药物对照。动脉粥样硬化通过血浆和心脏标记酶如乳酸脱氢酶(LDH)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)和碱性磷酸酶(ALP)的紊乱,血浆脂蛋白如VLDL、LDL水平升高,HDL水平降低,血浆脂质如甘油三酯(TG)、磷脂(PL)、游离脂肪酸(FFA)和胆固醇(CHO)水平升高来证实。脂质过氧化(LPO)升高,SOD、CAT和GPx等抗氧化酶活性降低,维生素C、维生素E和GSH水平降低。用CoRNS和Amla治疗后,标记酶、脂蛋白、脂质和抗氧化剂的水平保持在接近正常水平,从而证明了其降血脂和心脏保护特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective role of coenzyme Q10, riboflavin, niacin, selenium (CoRNS) and Emblica officinalis on cardiac abnormalities in experimental atherosclerosis

Atherosclerosis is characterized by the deposition of lipids in the artery wall and the infiltration of inflammatory cells, such as monocytes and lymphocytes. Hyperlipidemia is a major risk factor for the premature development of atherosclerosis and it has been shown to increase the incidence of myocardial ischemia and cardiac events. The aim of the present study is to evaluate the hypolipidemic and cardioprotective effect of CoQ10, riboflavin, niacin, selenium (CoRNS), and Emblica officinalis (Amla) in male wistar albino rats fed with high cholesterol diet (HCD) comprising of the normal chow supplemented with 4% cholesterol, 1% cholic acid for 30 days to develop atherosclerosis. After 30 days, Group IV animals were treated with Simvastatin as standard drug and Group V animals were treated with CoRNS and Amla. All the drugs were given by oral gavage for 30 days. Group III animals were served as drug control. Atherosclerosis was confirmed by disturbances in plasma and cardiac marker enzymes such as lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), increased levels of plasma lipoproteins like VLDL, LDL and decrease in HDL and increased levels of plasma lipids like triglycerides (TG), phospholipids (PL), free fatty acids (FFA) and cholesterol (CHO). There was significant increase in lipid peroxidation (LPO) and decreased activity of antioxidant enzymes such as SOD, CAT and GPx and also diminished levels of vitamin C, vitamin E and GSH. Treatment with CoRNS and Amla maintained the levels of marker enzymes, lipoproteins, lipids and also the antioxidants to near normal thereby proving its hypolipidemic and cardioprotective properties.

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