当代癌症治疗

D. Saranath, A. Khanna
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引用次数: 0

摘要

在全球公共卫生情景中,提供从“精准医学到精准护理”的有效护理方面急需解决的主要问题包括:“到2050年,抗菌素耐药性将使每年因抗菌素耐药性而死亡的估计人数减少1000万人”,以及“了解癌症生物学并由此彻底治愈癌症”,以及采用以患者为中心的方法进行转译护理。此外,需要推动在传染病和非传染性疾病中优先考虑“预防医学”。值得称赞的“可持续发展目标”,即到2030年将孕产妇死亡率从目前的216/10万活产降低到70/10万活产,通过集体努力是可行的。我们期待着以同样的方式解决抗菌素耐药性和癌症治疗问题。在社论中,我们重点关注当代癌症治疗方法在个体患者中的成功,表明美国FDA批准和全球实施的靶向治疗的使用和疗效。由于癌症的生物学复杂性和患者治疗反应的极端异质性,无论是对患者还是在相当程度上对肿瘤学家来说,癌症仍然是一个谜。癌症的祸根是癌细胞向远处器官的转移,这给癌症的治疗带来了不确定性。在过去的几年里,针对癌症分子病理学的新一代癌症治疗已经在肺癌、结肠直肠癌、乳腺癌、胰腺癌、脑癌、胃肠癌、头颈癌(包括口腔癌、肾癌、淋巴瘤、黑色素瘤、间皮瘤、前列腺癌、甲状腺癌、白血病和骨髓瘤)的治疗中发挥了作用,这些癌症都是针对个别患者的肿瘤量身定制的。该方法考虑到基因、环境和生活方式的个体差异,这将加强证据知情的决策。靶向分子疗法旨在通过中断驱动癌症生长的独特分子异常来治疗癌症。靶向治疗中使用的药物旨在干扰对Dhananjaya Saranath和Aparna Khanna的发育、生长和传播至关重要的特定生化途径
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contemporary cancer therapy
On the Public Health scenario globally the major issues in provision of effective care from ‘Precision Medicine to Precision Care’ that need urgent solutions include ‘Antimicrobial resistance to negate the estimated death of 10 million individuals annually due to Antimicrobial Resistance by 2050’, and ‘Understanding of Cancer Biology with consequent complete cure in Cancer’ and translation care with patient centered approach. Besides an impetus for prioritising ‘Preventive Medicine’ in both communicable and non-communicable diseases is needed. The laudable 'Sustainable Development Goal target' of reducing maternal mortality to 70/100,000 live births by 2030 from the current 216/100,000 is feasible due to collective efforts. We look forward to similarly tackling both the problems of antimicrobial resistance and cancer cure. In the editorial we focus on the success of Contemporary approach to Cancer Care for individual patients indicating the use and efficacy of US FDA approved and globally implemented targeted treatment. Cancer is still an enigma both to the patients and to a considerable extent to the oncologists, due to its biological complexity and extreme heterogeneity in treatment responses in patients. The bane of cancer is metastasis of the cancer cells to distant organs introducing uncertainties in cancer cure. Over the past several years, a next generation of cancer treatment targeted to the molecular pathology of cancer has made a difference in cancers of lung, colorectal, breast, pancreas, brain, gasterointestinal, head and neck cancers including oral cancer, kidney, lymphoma, melanoma, mesothelioma, prostate, thyroid, leukemia and myeloma, tailored to an individual patient's tumor. The approach takes into account individual variability in the genes, environment and lifestyle, and this will enhance evidence informed decision making. Targeted molecular therapy is designed to treat cancer by interrupting unique molecular abnormalities that drive cancer growth. The drugs used in targeted therapy are designed to interfere with a specific biochemical pathway central to the development, growth and spread of the Dhananjaya Saranath and Aparna Khanna
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