Manan Pareek , Abdellatif Aharaz , Mette Lundgren Nielsen , Oke Gerke , Margrét Leósdóttir , Jacob Eifer Møller , Niels Holmark Andersen , Peter M. Nilsson , Michael Hecht Olsen
{"title":"在瑞典老年健康人群中，未经治疗的糖尿病，而非空腹血糖受损，与左心室质量增加和同心型肥厚相关","authors":"Manan Pareek , Abdellatif Aharaz , Mette Lundgren Nielsen , Oke Gerke , Margrét Leósdóttir , Jacob Eifer Møller , Niels Holmark Andersen , Peter M. Nilsson , Michael Hecht Olsen","doi":"10.1016/j.ijcme.2015.10.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background/objectives</h3><p>To examine whether higher fasting plasma glucose (FPG) levels were independently associated with left ventricular (LV) mass and/or geometry in elderly, otherwise healthy subjects.</p></div><div><h3>Methods</h3><p>We tested cross-sectional associations between echocardiographically determined LV mass/geometric patterns, cardiovascular risk factors, and FPG categorized as normal fasting glucose (NFG), impaired fasting glucose (IFG), and untreated diabetes mellitus (DM), in 486 men and 207 women aged 56–79<!--> <!-->years without overt cardiovascular disease, who received no cardiovascular, anti-diabetic, or lipid-lowering drugs and had a preserved LV ejection fraction ><!--> <!-->50%.</p></div><div><h3>Results</h3><p>Unadjusted mean LV mass index (LVMI) was significantly greater among subjects with DM than those without (90<!--> <!-->+/−<!--> <!-->26<!--> <!-->g/m<sup>2</sup> vs. 85<!--> <!-->+/−<!--> <!-->20<!--> <!-->g/m<sup>2</sup>, p<!--> <!-->=<!--> <!-->0.01), as were both relative wall thickness (RWT) (0.43<!--> <!-->+/−<!--> <!-->0.09 vs. 0.40<!--> <!-->+/−<!--> <!-->0.08, p<!--> <!-->=<!--> <!-->0.01) and prevalence of concentric LV hypertrophy (LVH) (11% vs. 6%, p<!--> <!-->=<!--> <!-->0.03). However, only RWT remained significantly associated with the presence of DM after multivariable adjustment (p<!--> <!-->=<!--> <!-->0.04). Interaction analyses revealed that greater LVMI/LVH was predominantly associated with higher levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) among subjects with IFG or DM, but not NFG.</p></div><div><h3>Conclusions</h3><p>Subjects with untreated DM had higher values of LVMI and a greater prevalence of concentric LVH, but the associations were not independent of other risk factors. NT-proBNP was primarily associated with greater LV size in subjects with IFG or DM.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"9 ","pages":"Pages 39-47"},"PeriodicalIF":0.0000,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.10.005","citationCount":"6","resultStr":"{\"title\":\"Untreated diabetes mellitus, but not impaired fasting glucose, is associated with increased left ventricular mass and concentric hypertrophy in an elderly, healthy, Swedish population\",\"authors\":\"Manan Pareek , Abdellatif Aharaz , Mette Lundgren Nielsen , Oke Gerke , Margrét Leósdóttir , Jacob Eifer Møller , Niels Holmark Andersen , Peter M. Nilsson , Michael Hecht Olsen\",\"doi\":\"10.1016/j.ijcme.2015.10.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background/objectives</h3><p>To examine whether higher fasting plasma glucose (FPG) levels were independently associated with left ventricular (LV) mass and/or geometry in elderly, otherwise healthy subjects.</p></div><div><h3>Methods</h3><p>We tested cross-sectional associations between echocardiographically determined LV mass/geometric patterns, cardiovascular risk factors, and FPG categorized as normal fasting glucose (NFG), impaired fasting glucose (IFG), and untreated diabetes mellitus (DM), in 486 men and 207 women aged 56–79<!--> <!-->years without overt cardiovascular disease, who received no cardiovascular, anti-diabetic, or lipid-lowering drugs and had a preserved LV ejection fraction ><!--> <!-->50%.</p></div><div><h3>Results</h3><p>Unadjusted mean LV mass index (LVMI) was significantly greater among subjects with DM than those without (90<!--> <!-->+/−<!--> <!-->26<!--> <!-->g/m<sup>2</sup> vs. 85<!--> <!-->+/−<!--> <!-->20<!--> <!-->g/m<sup>2</sup>, p<!--> <!-->=<!--> <!-->0.01), as were both relative wall thickness (RWT) (0.43<!--> <!-->+/−<!--> <!-->0.09 vs. 0.40<!--> <!-->+/−<!--> <!-->0.08, p<!--> <!-->=<!--> <!-->0.01) and prevalence of concentric LV hypertrophy (LVH) (11% vs. 6%, p<!--> <!-->=<!--> <!-->0.03). However, only RWT remained significantly associated with the presence of DM after multivariable adjustment (p<!--> <!-->=<!--> <!-->0.04). Interaction analyses revealed that greater LVMI/LVH was predominantly associated with higher levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) among subjects with IFG or DM, but not NFG.</p></div><div><h3>Conclusions</h3><p>Subjects with untreated DM had higher values of LVMI and a greater prevalence of concentric LVH, but the associations were not independent of other risk factors. NT-proBNP was primarily associated with greater LV size in subjects with IFG or DM.</p></div>\",\"PeriodicalId\":73333,\"journal\":{\"name\":\"IJC metabolic & endocrine\",\"volume\":\"9 \",\"pages\":\"Pages 39-47\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.10.005\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IJC metabolic & endocrine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214762415300128\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJC metabolic & endocrine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214762415300128","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Untreated diabetes mellitus, but not impaired fasting glucose, is associated with increased left ventricular mass and concentric hypertrophy in an elderly, healthy, Swedish population
Background/objectives
To examine whether higher fasting plasma glucose (FPG) levels were independently associated with left ventricular (LV) mass and/or geometry in elderly, otherwise healthy subjects.
Methods
We tested cross-sectional associations between echocardiographically determined LV mass/geometric patterns, cardiovascular risk factors, and FPG categorized as normal fasting glucose (NFG), impaired fasting glucose (IFG), and untreated diabetes mellitus (DM), in 486 men and 207 women aged 56–79 years without overt cardiovascular disease, who received no cardiovascular, anti-diabetic, or lipid-lowering drugs and had a preserved LV ejection fraction > 50%.
Results
Unadjusted mean LV mass index (LVMI) was significantly greater among subjects with DM than those without (90 +/− 26 g/m2 vs. 85 +/− 20 g/m2, p = 0.01), as were both relative wall thickness (RWT) (0.43 +/− 0.09 vs. 0.40 +/− 0.08, p = 0.01) and prevalence of concentric LV hypertrophy (LVH) (11% vs. 6%, p = 0.03). However, only RWT remained significantly associated with the presence of DM after multivariable adjustment (p = 0.04). Interaction analyses revealed that greater LVMI/LVH was predominantly associated with higher levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) among subjects with IFG or DM, but not NFG.
Conclusions
Subjects with untreated DM had higher values of LVMI and a greater prevalence of concentric LVH, but the associations were not independent of other risk factors. NT-proBNP was primarily associated with greater LV size in subjects with IFG or DM.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
