Rameshwar L. Bang, Abdul Latif Al-Bader, Prem N Sharma, Alice Babu Mattapallil, Abdulla I. Behbehani, Hussein Dashti
{"title":"瘢痕疙瘩和正常瘢痕患者血清、正常皮肤和瘢痕组织中微量元素含量","authors":"Rameshwar L. Bang, Abdul Latif Al-Bader, Prem N Sharma, Alice Babu Mattapallil, Abdulla I. Behbehani, Hussein Dashti","doi":"10.1002/jtra.10001","DOIUrl":null,"url":null,"abstract":"Wound healing is a normal physiological process that occurs after injury. Scars are usually formed, and the nature of the scar depends on the balance between the formed and degraded collagen during healing. A balanced production and degradation of collagen in wound healing results in the formation of a normal scar whereas an imbalance produces what is known as keloid scar. The factors that cause an imbalance are not well identified, although many factors, such as immunity, genetic, ischaemia, hormonal, growth, and nutritional factors, are blamed. This study was undertaken to investigate trace elements level in the serum, normal skin, and scar tissue of patients with normal and keloid scars. Copper (Cu), zinc (Zn), selenium (Se), and manganese (Mn) levels were estimated in 100 (50 with normal scars and the others with keloids) patients. The serum level of Zn was found to be higher in keloid scar patients, and this increase was highly significant (P < 0.0001). The level of Cu was significantly higher (P < 0.0001) in the normal skin and scar tissues of keloid patients. Trace element levels in scar tissues were observed to be lower in comparison to normal skin trace element content in both groups. The significant changes of Zn in serum and Cu in skin and scar tissues of keloid patients as noted in this study may suggest their role in the regulation of behavior of scar formation in wound healing. J. Trace Elem. Exp. Med. 15:57–66, 2002. © 2002 Wiley-Liss, Inc.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"15 1","pages":"57-66"},"PeriodicalIF":0.0000,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.10001","citationCount":"18","resultStr":"{\"title\":\"Trace elements content in serum, normal skin, and scar tissues of keloid and normal scar patients\",\"authors\":\"Rameshwar L. Bang, Abdul Latif Al-Bader, Prem N Sharma, Alice Babu Mattapallil, Abdulla I. Behbehani, Hussein Dashti\",\"doi\":\"10.1002/jtra.10001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Wound healing is a normal physiological process that occurs after injury. Scars are usually formed, and the nature of the scar depends on the balance between the formed and degraded collagen during healing. A balanced production and degradation of collagen in wound healing results in the formation of a normal scar whereas an imbalance produces what is known as keloid scar. The factors that cause an imbalance are not well identified, although many factors, such as immunity, genetic, ischaemia, hormonal, growth, and nutritional factors, are blamed. This study was undertaken to investigate trace elements level in the serum, normal skin, and scar tissue of patients with normal and keloid scars. Copper (Cu), zinc (Zn), selenium (Se), and manganese (Mn) levels were estimated in 100 (50 with normal scars and the others with keloids) patients. The serum level of Zn was found to be higher in keloid scar patients, and this increase was highly significant (P < 0.0001). The level of Cu was significantly higher (P < 0.0001) in the normal skin and scar tissues of keloid patients. Trace element levels in scar tissues were observed to be lower in comparison to normal skin trace element content in both groups. The significant changes of Zn in serum and Cu in skin and scar tissues of keloid patients as noted in this study may suggest their role in the regulation of behavior of scar formation in wound healing. J. Trace Elem. Exp. 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引用次数: 18
Trace elements content in serum, normal skin, and scar tissues of keloid and normal scar patients
Wound healing is a normal physiological process that occurs after injury. Scars are usually formed, and the nature of the scar depends on the balance between the formed and degraded collagen during healing. A balanced production and degradation of collagen in wound healing results in the formation of a normal scar whereas an imbalance produces what is known as keloid scar. The factors that cause an imbalance are not well identified, although many factors, such as immunity, genetic, ischaemia, hormonal, growth, and nutritional factors, are blamed. This study was undertaken to investigate trace elements level in the serum, normal skin, and scar tissue of patients with normal and keloid scars. Copper (Cu), zinc (Zn), selenium (Se), and manganese (Mn) levels were estimated in 100 (50 with normal scars and the others with keloids) patients. The serum level of Zn was found to be higher in keloid scar patients, and this increase was highly significant (P < 0.0001). The level of Cu was significantly higher (P < 0.0001) in the normal skin and scar tissues of keloid patients. Trace element levels in scar tissues were observed to be lower in comparison to normal skin trace element content in both groups. The significant changes of Zn in serum and Cu in skin and scar tissues of keloid patients as noted in this study may suggest their role in the regulation of behavior of scar formation in wound healing. J. Trace Elem. Exp. Med. 15:57–66, 2002. © 2002 Wiley-Liss, Inc.