瘢痕疙瘩和正常瘢痕患者血清、正常皮肤和瘢痕组织中微量元素含量

Rameshwar L. Bang, Abdul Latif Al-Bader, Prem N Sharma, Alice Babu Mattapallil, Abdulla I. Behbehani, Hussein Dashti
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引用次数: 18

摘要

伤口愈合是受伤后发生的一个正常的生理过程。疤痕通常是形成的,疤痕的性质取决于愈合过程中形成和降解的胶原蛋白之间的平衡。在伤口愈合过程中,胶原蛋白的平衡产生和降解会形成正常的疤痕,而不平衡则会产生所谓的瘢痕疙瘩。导致失衡的因素还没有很好地确定,尽管许多因素,如免疫力、遗传、缺血、激素、生长和营养因素,都被归咎于此。本研究旨在调查正常瘢痕和瘢痕疙瘩患者血清、正常皮肤和瘢痕组织中的微量元素水平。估计了100名(50名正常瘢痕患者和其他瘢痕疙瘩患者)患者的铜(Cu)、锌(Zn)、硒(Se)和锰(Mn)水平。瘢痕疙瘩患者的血清Zn水平较高,并且这种增加非常显著(P<;0.0001)。瘢痕疙瘩患者正常皮肤和瘢痕组织中Cu水平显著较高(P<:0.0001)。与两组正常皮肤微量元素含量相比,瘢痕组织中的微量元素水平较低。如本研究所述,瘢痕疙瘩患者血清中Zn和皮肤及瘢痕组织中Cu的显著变化可能表明它们在伤口愈合中对瘢痕形成行为的调节作用。J.Trace Elem。《实验医学》,2002年15月57日至66日。©2002 Wiley-Liss,股份有限公司。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trace elements content in serum, normal skin, and scar tissues of keloid and normal scar patients
Wound healing is a normal physiological process that occurs after injury. Scars are usually formed, and the nature of the scar depends on the balance between the formed and degraded collagen during healing. A balanced production and degradation of collagen in wound healing results in the formation of a normal scar whereas an imbalance produces what is known as keloid scar. The factors that cause an imbalance are not well identified, although many factors, such as immunity, genetic, ischaemia, hormonal, growth, and nutritional factors, are blamed. This study was undertaken to investigate trace elements level in the serum, normal skin, and scar tissue of patients with normal and keloid scars. Copper (Cu), zinc (Zn), selenium (Se), and manganese (Mn) levels were estimated in 100 (50 with normal scars and the others with keloids) patients. The serum level of Zn was found to be higher in keloid scar patients, and this increase was highly significant (P < 0.0001). The level of Cu was significantly higher (P < 0.0001) in the normal skin and scar tissues of keloid patients. Trace element levels in scar tissues were observed to be lower in comparison to normal skin trace element content in both groups. The significant changes of Zn in serum and Cu in skin and scar tissues of keloid patients as noted in this study may suggest their role in the regulation of behavior of scar formation in wound healing. J. Trace Elem. Exp. Med. 15:57–66, 2002. © 2002 Wiley-Liss, Inc.
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