{"title":"锂对大鼠颅骨蛛网膜和硬脑膜胶原的副作用:定量超微结构研究","authors":"Margaret Tzaphlidou","doi":"10.1002/jtra.10022","DOIUrl":null,"url":null,"abstract":"Lithium is widely used in medicine as an antidepressive drug. Despite abundant literature on the subject, questions on the effects of lithium on collagen, which is one of the major components of tissues and organs, are far from being answered. We have examined the effects of lithium chloride (1.5 meq/kg of body weight) on rat cranial arachnoid and dura mater collagen fibrils by electron microscopy and image analysis. Animals were sacrificed 1 day, 2, 6, and 12 months after the end of a 30-consecutive days experimental period. In all cases investigated, severe structural abnormalities in collagen fibrils, at the ultrastructural level, were found. These abnormalities consist of decreased mean diameter and irregularity of shape of collagen fibrils (when viewed in cross sections) as well as marked disorganization in the packing of the fibrils. The observed alterations seem to be permanent. J. Trace Elem. Exp. Med. 16:17–26, 2003. © 2003 Wiley-Liss, Inc.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"16 1","pages":"17-26"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.10022","citationCount":"3","resultStr":"{\"title\":\"Side effects of lithium on rat cranial arachnoid and dura mater collagen: A quantitative ultrastructural study\",\"authors\":\"Margaret Tzaphlidou\",\"doi\":\"10.1002/jtra.10022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lithium is widely used in medicine as an antidepressive drug. Despite abundant literature on the subject, questions on the effects of lithium on collagen, which is one of the major components of tissues and organs, are far from being answered. We have examined the effects of lithium chloride (1.5 meq/kg of body weight) on rat cranial arachnoid and dura mater collagen fibrils by electron microscopy and image analysis. Animals were sacrificed 1 day, 2, 6, and 12 months after the end of a 30-consecutive days experimental period. In all cases investigated, severe structural abnormalities in collagen fibrils, at the ultrastructural level, were found. These abnormalities consist of decreased mean diameter and irregularity of shape of collagen fibrils (when viewed in cross sections) as well as marked disorganization in the packing of the fibrils. The observed alterations seem to be permanent. J. Trace Elem. Exp. Med. 16:17–26, 2003. © 2003 Wiley-Liss, Inc.\",\"PeriodicalId\":101243,\"journal\":{\"name\":\"The Journal of Trace Elements in Experimental Medicine\",\"volume\":\"16 1\",\"pages\":\"17-26\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jtra.10022\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Trace Elements in Experimental Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jtra.10022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Trace Elements in Experimental Medicine","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jtra.10022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Side effects of lithium on rat cranial arachnoid and dura mater collagen: A quantitative ultrastructural study
Lithium is widely used in medicine as an antidepressive drug. Despite abundant literature on the subject, questions on the effects of lithium on collagen, which is one of the major components of tissues and organs, are far from being answered. We have examined the effects of lithium chloride (1.5 meq/kg of body weight) on rat cranial arachnoid and dura mater collagen fibrils by electron microscopy and image analysis. Animals were sacrificed 1 day, 2, 6, and 12 months after the end of a 30-consecutive days experimental period. In all cases investigated, severe structural abnormalities in collagen fibrils, at the ultrastructural level, were found. These abnormalities consist of decreased mean diameter and irregularity of shape of collagen fibrils (when viewed in cross sections) as well as marked disorganization in the packing of the fibrils. The observed alterations seem to be permanent. J. Trace Elem. Exp. Med. 16:17–26, 2003. © 2003 Wiley-Liss, Inc.