锂对大鼠颅骨蛛网膜和硬脑膜胶原的副作用:定量超微结构研究

Margaret Tzaphlidou
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引用次数: 3

摘要

锂作为一种抗抑郁药物被广泛应用于医学。尽管有大量关于这一主题的文献,但关于锂对胶原蛋白的影响的问题远未得到回答,胶原蛋白是组织和器官的主要成分之一。我们通过电子显微镜和图像分析研究了氯化锂(1.5meq/kg体重)对大鼠颅骨蛛网膜和硬脑膜胶原纤维的影响。在连续30天的实验期结束后1天、2个月、6个月和12个月处死动物。在所有研究的病例中,发现胶原原纤维在超微结构水平上存在严重的结构异常。这些异常包括胶原原纤维的平均直径减小和形状不规则(当在横截面中观察时),以及原纤维的堆积明显紊乱。观察到的变化似乎是永久性的。J.Trace Elem。Exp.Med.16:17-262003。©2003 Wiley-Liss,股份有限公司。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Side effects of lithium on rat cranial arachnoid and dura mater collagen: A quantitative ultrastructural study
Lithium is widely used in medicine as an antidepressive drug. Despite abundant literature on the subject, questions on the effects of lithium on collagen, which is one of the major components of tissues and organs, are far from being answered. We have examined the effects of lithium chloride (1.5 meq/kg of body weight) on rat cranial arachnoid and dura mater collagen fibrils by electron microscopy and image analysis. Animals were sacrificed 1 day, 2, 6, and 12 months after the end of a 30-consecutive days experimental period. In all cases investigated, severe structural abnormalities in collagen fibrils, at the ultrastructural level, were found. These abnormalities consist of decreased mean diameter and irregularity of shape of collagen fibrils (when viewed in cross sections) as well as marked disorganization in the packing of the fibrils. The observed alterations seem to be permanent. J. Trace Elem. Exp. Med. 16:17–26, 2003. © 2003 Wiley-Liss, Inc.
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