自闭症儿童的锌状况

Özgür Yorbik, Cemal Akay, Ahmet Sayal, Adnan Cansever, Teoman Söhmen, Ayhan O. Çavdar
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引用次数: 34

摘要

过渡金属锌是包括中枢神经系统(CNS)在内的生物系统正常发育和功能的必需元素。锌可能是自闭症儿童亚组病因和症状的重要微量元素,因为它是许多蛋白质的重要催化或结构元素,对神经活动和控制神经元死亡很重要。本研究的目的是评估自闭症儿童的锌状况。分别用原子吸收分光光度法测定了45名和39名自闭症儿童的血浆、红细胞和头发锌水平。选择41名同年龄组的健康儿童作为对照。发现自闭症儿童的血浆和红细胞锌水平显著低于正常水平(P<;0.05)。与正常土耳其儿童相比,患者的平均头发锌水平也较低。这些结果可能表明自闭症儿童长期缺锌或锌代谢异常。需要进一步的研究来阐明潜在的机制。J.追踪。Elem。Exp.Med.17:101–1072004。©2004 Wiley-Liss,股份有限公司。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Zinc status in autistic children
The transition metal zinc is an essential element for normal development and function of biological systems including the central nervous system (CNS). Zinc may be an important trace element for the etiology and symptoms of subgroups of autistic children because it is an essential catalytic or structural element of many proteins and important for neural activity and the control of neuronal death. The aim of this study was to evaluate zinc status in children with autistic disorder. Plasma, erythrocyte, and hair zinc levels were measured by atomic absorption spectrophotometry in the 45 and 39 autistic children, respectively. Forty-one healthy children in the same age group were selected as controls. Plasma and erythrocyte zinc levels in the autistic children were found to be significantly lower than normal (P < 0.05). The mean hair zinc level of the patients was also low when compared with that obtained from normal Turkish children. These results may indicate chronic zinc deficiency or metabolic abnormality of zinc in autistic children. Further studies are required to clarify underlying mechanisms. J. Trace. Elem. Exp. Med. 17:101–107, 2004. © 2004 Wiley-Liss, Inc.
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