糖皮质激素信号传导和高脂饮食对体内脂肪生成的影响。

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2023-11-07 DOI:10.1016/j.steroids.2023.109336

Noah K. Babel, Brian J. Feldman

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引用次数: 0

摘要

我们的研究使用糖皮质激素作为医学相关的分子探针来鉴定先前未被识别的ADAMTS1 PTN Wnt途径。我们阐明了该途径在调节脂肪前体细胞（APC）行为中的作用，以响应系统性提示（如热量摄入增加）增殖或分化。此外，我们的研究确定非肌肉肌球蛋白蛋白MYH9是该途径在体内调节脂肪生成的关键靶点。这些发现为开发治疗肥胖和相关代谢紊乱的新疗法提供了策略。

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Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo

Our research used glucocorticoids as a medically relevant molecular probe to identify a previously unrecognized ADAMTS1-PTN-Wnt pathway. We elucidated the role of this pathway in regulating adipose precursor cell (APC) behavior to either proliferate or differentiate in response to systemic cues, such as elevated caloric intake. Further, our studies identified the non-muscle myosin protein MYH9 as a key target of this pathway to modulate adipogenesis in vivo. These findings enable strategies toward developing novel therapeutics for obesity and related metabolic disorders.

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.