癌症治疗中用于药物递送的细胞外囊泡。

IF 3.7 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Biological Procedures Online Pub Date : 2023-11-09 DOI:10.1186/s12575-023-00220-3

Li Wang, Xin Yu, Juan Zhou, Chunxia Su

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引用次数: 0

摘要

细胞外囊泡（EVs）是一种纳米级囊泡，来源于通过转运生物活性分子介导细胞间通讯的细胞。它们在各种生理和病理条件下发挥着重要作用。电动汽车作为疾病的新型生物标志物、治疗剂和药物递送载体具有巨大的潜力。此外，电动汽车作为新型药物递送载体在临床前环境中表现出显著优势。在这篇综述中，我们讨论了EVs的生物发生、特征及其在癌症中的作用。我们总结了电动汽车作为一种天然载体在癌症治疗中的应用。我们强调了现有的挑战，阐明了重要问题，并提出了有效应对这些挑战的建议。

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Extracellular Vesicles for Drug Delivery in Cancer Treatment.

Extracellular vesicles (EVs) are nanoscale vesicles derived from cells that mediate intercellular communication by transporting bioactive molecules. They play significant roles in various physiological and pathological conditions. EVs hold great potential as novel biomarkers of diseases, therapeutic agents, and drug delivery vehicles. Furthermore, EVs as novel drug delivery vehicles have demonstrated significant advantages in preclinical settings. In this review, we discussed the biogenesis and characteristics of EVs and their functions in cancer. We summarize the therapeutic applications of EVs as a natural delivery vehicles in cancer therapy. We highlight the existing challenges, illuminate vital questions, and propose recommendations to effectively address them effectively.

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来源期刊

Biological Procedures Online 生物-生化研究方法

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： iological Procedures Online publishes articles that improve access to techniques and methods in the medical and biological sciences. We are also interested in short but important research discoveries, such as new animal disease models. Topics of interest include, but are not limited to: Reports of new research techniques and applications of existing techniques Technical analyses of research techniques and published reports Validity analyses of research methods and approaches to judging the validity of research reports Application of common research methods Reviews of existing techniques Novel/important product information Biological Procedures Online places emphasis on multidisciplinary approaches that integrate methodologies from medicine, biology, chemistry, imaging, engineering, bioinformatics, computer science, and systems analysis.