使用多动症的多基因风险评分预测酒精依赖性多动症。

IF 1.6 3区 医学 Q3 GENETICS & HEREDITY
Kejal H. S. Patel, G. Bragi Walters, Hreinn Stefánsson, Kári Stefánsson, Franziska Degenhardt, Markus Nothen, Tracey Van Der Veen, Ditte Demontis, Anders Borglum, Mark Kristiansen, Nicholas J. Bass, Andrew McQuillin
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引用次数: 0

摘要

注意力缺陷多动障碍(ADHD)是一种神经发育障碍,具有高度的共病性,包括药物滥用。我们的目的是评估多动症多基因风险评分(PRS)是否可以预测酒精依赖症(AD)的多动症诊断。1223人产生了ADHD PRS 有ADHD诊断信息的AD受试者和1818名健康对照。比较ADHD PRS的分布,以评估健康对照组和患有和不患有ADHD的AD病例之间的差异。我们发现,在患有多动症的AD队列中,多动症PRS均值增加(平均值0.30,标准差(SD)0.92;p = 3.9 × 10-6);并且没有ADHD(平均 - 0.00,标准差1.00;p = 5.2 × 10-5)与健康对照受试者相比(平均值 - 0.17,SD 0.99)。ADHD患者的ADHD PRS均值在AD组内存在差异,ADHD患者中ADHD的PRS均值较高,比值比(OR)为1.34,置信区间(CI)为1.10-1.65;p = 0.002。这项研究表明,在患有合并AD的个体中,ADHD PRS与ADHD风险之间存在正相关关系,这表明多动症PRS可能有助于识别患有ADHD风险较高或较低的个体。在ADHD PRS被认为是一种可靠的诊断生物标志物之前,还需要进行进一步的大规模研究来确认结果的可靠性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD

Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a high degree of comorbidity, including substance misuse. We aimed to assess whether ADHD polygenic risk scores (PRS) could predict ADHD diagnosis in alcohol dependence (AD). ADHD PRS were generated for 1223 AD subjects with ADHD diagnosis information and 1818 healthy controls. ADHD PRS distributions were compared to evaluate the differences between healthy controls and AD cases with and without ADHD. We found increased ADHD PRS means in the AD cohort with ADHD (mean 0.30, standard deviation (SD) 0.92; p = 3.9 × 10−6); and without ADHD (mean − 0.00, SD 1.00; p = 5.2 × 10−5) compared to the healthy control subjects (mean − 0.17, SD 0.99). The ADHD PRS means differed within the AD group with a higher ADHD PRS mean in those with ADHD, odds ratio (OR) 1.34, confidence interval (CI) 1.10 to 1.65; p = 0.002. This study showed a positive relationship between ADHD PRS and risk of ADHD in individuals with co-occurring AD indicating that ADHD PRS may have utility in identifying individuals that are at a higher or lower risk of ADHD. Further larger studies need to be conducted to confirm the reliability of the results before ADHD PRS can be considered as a robust biomarker for diagnosis.

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来源期刊
CiteScore
5.90
自引率
7.10%
发文量
40
审稿时长
4-8 weeks
期刊介绍: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) , provides a forum for experimental and clinical investigations of the genetic mechanisms underlying neurologic and psychiatric disorders. It is a resource for novel genetics studies of the heritable nature of psychiatric and other nervous system disorders, characterized at the molecular, cellular or behavior levels. Neuropsychiatric Genetics publishes eight times per year.
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