拉丁美洲跨祖先强迫症基因组学研究(LATINO):研究方案。

IF 1.6 3区 医学 Q3 GENETICS & HEREDITY
James J. Crowley, Carolina Cappi, Marcos E. Ochoa-Panaifo, Renee M. Frederick, Minjee Kook, Andrew D. Wiese, Diana Rancourt, Elizabeth G. Atkinson, Paola Giusti-Rodriguez, Jacey L. Anderberg, Latin American Trans-ancestry INitiative for OCD genomics, Brazilian Obsessive-Compulsive Spectrum Disorder Working Group, Jonathan S. Abramowitz, Victor R. Adorno, Cinthia Aguirre, Gilberto S. Alves, Gustavo S. Alves, NaEshia Ancalade, Alejandro A. Arellano Espinosa, Paul D. Arnold, Daphne M. Ayton, Izabela G. Barbosa, Laura Marcela Barón Castano, Cynthia N. Barrera, María Celeste Berardo, Dayan Berrones, John R. Best, Tim B. Bigdeli, Christie L. Burton, Joseph D. Buxbaum, Jennifer L. Callahan, Maria Cecília B. Carneiro, Sandra L. Cepeda, Evelyn Chazelle, Jessica M. Chire, Macarena Churruca Munoz, Pamela Claisse Quiroz, Journa Cobite, Jonathan S. Comer, Daniel L. Costa, Jennifer Crosbie, Victor O. Cruz, Guillermo Dager, Luisa F. Daza, Anabel de la Rosa-Gómez, Daniela del Río, Fernanda Z. Delage, Carolina B. Dreher, Lucila Fay, Tomas Fazio, Ygor A. Ferrão, Gabriela M. Ferreira, Edith G. Figueroa, Leonardo F. Fontenelle, Diego A. Forero, Daniele T. H. Fragoso, Bharathi S. Gadad, Sheldon R. Garrison, Andres González, Laura D. Gonzalez, Marco A. González, Polaris Gonzalez-Barrios, Wayne K. Goodman, Dorothy E. Grice, Jerry Guintivano, Daniel G. Guttfreund, Andrew G. Guzick, Matthew W. Halvorsen, Joseph D. Hovey, Hailiang Huang, Jonathan Irreño-Sotomonte, Reinhard Janssen-Aguilar, Matias Jensen, Alexandra Z. Jimenez Reynolds, Joali Alexandra Juárez Lujambio, Nasim Khalfe, Madison A. Knutsen, Caleb Lack, Nuria Lanzagorta, Monicke O. Lima, Melanie O. Longhurst, David A. Lozada Martinez, Elba S. Luna, Andrea H. Marques, Molly S. Martinez, Maria de Los Angeles Matos, Caitlyn E. Maye, Joseph F. McGuire, Gabriela Menezes, Charlene Minaya, Tomás Miño, Sara M. Mithani, Circe Montes de Oca, Alonso Morales-Rivero, Maria E. Moreira-de-Oliveira, Olivia J. Morris, Sandra I. Muñoz, Zainab Naqqash, Ambar A. Núñez Bracho, Belinda E. Núñez Bracho, Maria Corina Ochoa Rojas, Luis A. Olavarria Castaman, Trinidad Olivos Balmaceda, Iliana Ortega, Darpan I. Patel, Ainsley K. Patrick, Mariel Paz y Mino, Jose L. Perales Orellana, Bárbara Perdigão Stumpf, Tamara Peregrina, Tania Pérez Duarte, Kelly L. Piacsek, Maritza Placencia, María Belén Prieto, Lucas C. Quarantini, Yana Quarantini-Alvim, Renato T. Ramos, Iaroslava C. Ramos, Vanessa R. Ramos, Kesley A. Ramsey, Elise V. Ray, Margaret A. Richter, Bradley C. Riemann, Juan C. Rivas, Maria C. Rosario, Camilo J. Ruggero, Angel A. Ruiz-Chow, Alejandra Ruiz-Velasco, Melisa N. Sagarnaga, Aline S. Sampaio, Leonardo C. Saraiva, Russell J. Schachar, Sophie C. Schneider, Ethan J. Schweissing, Laura D. Seligman, Roseli G. Shavitt, Keaton J. Soileau, S. Evelyn Stewart, Shaina B. Storch, Emily R. Strouphauer, Vissente Tapia Cuevas, Kiara R. Timpano, Beatriz Treviño-de la Garza, Alexie Vallejo-Silva, Javier Vargas-Medrano, María I. Vásquez, Guadalupe Vidal Martinez, Saira A. Weinzimmer, Mauricio A. Yanez, Gwyneth Zai, Lina M. Zapata-Restrepo, Luz M. Zappa, Raquel M. Zepeda-Burgos, Anthony W. Zoghbi, Euripedes C. Miguel, Carolyn I. Rodriguez, Mayra C. Martinez Mallen, Pablo R. Moya, Tania Borda, María Beatriz Moyano, Manuel Mattheisen, Stacey Pereira, Gabriel Lázaro-Muñoz, Karen G. Martinez-Gonzalez, Michele T. Pato, Humberto Nicolini, Eric A. Storch
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Chire,&nbsp;Macarena Churruca Munoz,&nbsp;Pamela Claisse Quiroz,&nbsp;Journa Cobite,&nbsp;Jonathan S. Comer,&nbsp;Daniel L. Costa,&nbsp;Jennifer Crosbie,&nbsp;Victor O. Cruz,&nbsp;Guillermo Dager,&nbsp;Luisa F. Daza,&nbsp;Anabel de la Rosa-Gómez,&nbsp;Daniela del Río,&nbsp;Fernanda Z. Delage,&nbsp;Carolina B. Dreher,&nbsp;Lucila Fay,&nbsp;Tomas Fazio,&nbsp;Ygor A. Ferrão,&nbsp;Gabriela M. Ferreira,&nbsp;Edith G. Figueroa,&nbsp;Leonardo F. Fontenelle,&nbsp;Diego A. Forero,&nbsp;Daniele T. H. Fragoso,&nbsp;Bharathi S. Gadad,&nbsp;Sheldon R. Garrison,&nbsp;Andres González,&nbsp;Laura D. Gonzalez,&nbsp;Marco A. González,&nbsp;Polaris Gonzalez-Barrios,&nbsp;Wayne K. Goodman,&nbsp;Dorothy E. Grice,&nbsp;Jerry Guintivano,&nbsp;Daniel G. Guttfreund,&nbsp;Andrew G. Guzick,&nbsp;Matthew W. Halvorsen,&nbsp;Joseph D. Hovey,&nbsp;Hailiang Huang,&nbsp;Jonathan Irreño-Sotomonte,&nbsp;Reinhard Janssen-Aguilar,&nbsp;Matias Jensen,&nbsp;Alexandra Z. Jimenez Reynolds,&nbsp;Joali Alexandra Juárez Lujambio,&nbsp;Nasim Khalfe,&nbsp;Madison A. Knutsen,&nbsp;Caleb Lack,&nbsp;Nuria Lanzagorta,&nbsp;Monicke O. Lima,&nbsp;Melanie O. Longhurst,&nbsp;David A. Lozada Martinez,&nbsp;Elba S. Luna,&nbsp;Andrea H. Marques,&nbsp;Molly S. Martinez,&nbsp;Maria de Los Angeles Matos,&nbsp;Caitlyn E. Maye,&nbsp;Joseph F. McGuire,&nbsp;Gabriela Menezes,&nbsp;Charlene Minaya,&nbsp;Tomás Miño,&nbsp;Sara M. Mithani,&nbsp;Circe Montes de Oca,&nbsp;Alonso Morales-Rivero,&nbsp;Maria E. Moreira-de-Oliveira,&nbsp;Olivia J. Morris,&nbsp;Sandra I. Muñoz,&nbsp;Zainab Naqqash,&nbsp;Ambar A. Núñez Bracho,&nbsp;Belinda E. Núñez Bracho,&nbsp;Maria Corina Ochoa Rojas,&nbsp;Luis A. Olavarria Castaman,&nbsp;Trinidad Olivos Balmaceda,&nbsp;Iliana Ortega,&nbsp;Darpan I. Patel,&nbsp;Ainsley K. Patrick,&nbsp;Mariel Paz y Mino,&nbsp;Jose L. Perales Orellana,&nbsp;Bárbara Perdigão Stumpf,&nbsp;Tamara Peregrina,&nbsp;Tania Pérez Duarte,&nbsp;Kelly L. Piacsek,&nbsp;Maritza Placencia,&nbsp;María Belén Prieto,&nbsp;Lucas C. Quarantini,&nbsp;Yana Quarantini-Alvim,&nbsp;Renato T. Ramos,&nbsp;Iaroslava C. Ramos,&nbsp;Vanessa R. Ramos,&nbsp;Kesley A. Ramsey,&nbsp;Elise V. Ray,&nbsp;Margaret A. Richter,&nbsp;Bradley C. Riemann,&nbsp;Juan C. Rivas,&nbsp;Maria C. Rosario,&nbsp;Camilo J. Ruggero,&nbsp;Angel A. Ruiz-Chow,&nbsp;Alejandra Ruiz-Velasco,&nbsp;Melisa N. Sagarnaga,&nbsp;Aline S. Sampaio,&nbsp;Leonardo C. Saraiva,&nbsp;Russell J. Schachar,&nbsp;Sophie C. Schneider,&nbsp;Ethan J. Schweissing,&nbsp;Laura D. Seligman,&nbsp;Roseli G. Shavitt,&nbsp;Keaton J. Soileau,&nbsp;S. Evelyn Stewart,&nbsp;Shaina B. Storch,&nbsp;Emily R. Strouphauer,&nbsp;Vissente Tapia Cuevas,&nbsp;Kiara R. Timpano,&nbsp;Beatriz Treviño-de la Garza,&nbsp;Alexie Vallejo-Silva,&nbsp;Javier Vargas-Medrano,&nbsp;María I. Vásquez,&nbsp;Guadalupe Vidal Martinez,&nbsp;Saira A. Weinzimmer,&nbsp;Mauricio A. Yanez,&nbsp;Gwyneth Zai,&nbsp;Lina M. Zapata-Restrepo,&nbsp;Luz M. Zappa,&nbsp;Raquel M. Zepeda-Burgos,&nbsp;Anthony W. Zoghbi,&nbsp;Euripedes C. Miguel,&nbsp;Carolyn I. Rodriguez,&nbsp;Mayra C. Martinez Mallen,&nbsp;Pablo R. Moya,&nbsp;Tania Borda,&nbsp;María Beatriz Moyano,&nbsp;Manuel Mattheisen,&nbsp;Stacey Pereira,&nbsp;Gabriel Lázaro-Muñoz,&nbsp;Karen G. Martinez-Gonzalez,&nbsp;Michele T. Pato,&nbsp;Humberto Nicolini,&nbsp;Eric A. Storch","doi":"10.1002/ajmg.b.32962","DOIUrl":null,"url":null,"abstract":"<p>Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but &gt;95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. 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引用次数: 0

摘要

强迫症是一种使人衰弱的精神障碍。在世界范围内,其患病率约为2%,其病因大多未知。识别导致强迫症的生物学因素将阐明潜在机制,并可能有助于改善治疗结果。强迫症的基因组研究开始揭示长期寻求的风险基因座,但目前分析的病例中,95%以上是同源欧洲血统。如果不加以解决,这种以欧洲为中心的偏见将导致强迫症基因组研究结果对欧洲血统的个体比其他祖先更准确,从而导致基因组学未来潜在应用中的健康差异。在这篇研究方案论文中,我们描述了OCD基因组学的拉丁美洲跨祖先INinitiative(LATINO,https://www.latinostudy.org)。LATINO是一个由来自拉丁美洲、美国和加拿大的研究人员组成的新网络,他们已经开始以文化敏感和道德的方式从5000例具有拉丁美洲血统的表型丰富的强迫症病例中收集DNA和临床数据。在这个项目中,我们将利用跨祖先基因组分析来加速强迫症风险基因座的识别,精细绘制假定的因果变异图,并提高不同人群中多基因风险评分的表现。我们还将利用丰富的临床数据来检查治疗反应的遗传学、生物学上合理的强迫症亚型和症状维度。此外,LATINO将通过与拉丁美洲研究人员合作开发和提供的各种培训,帮助阐明不同文化中强迫症临床表现的多样性。我们相信这项研究将推进全球心理健康发现和公平的重要目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

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来源期刊
CiteScore
5.90
自引率
7.10%
发文量
40
审稿时长
4-8 weeks
期刊介绍: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) , provides a forum for experimental and clinical investigations of the genetic mechanisms underlying neurologic and psychiatric disorders. It is a resource for novel genetics studies of the heritable nature of psychiatric and other nervous system disorders, characterized at the molecular, cellular or behavior levels. Neuropsychiatric Genetics publishes eight times per year.
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