James J. Crowley, Carolina Cappi, Marcos E. Ochoa-Panaifo, Renee M. Frederick, Minjee Kook, Andrew D. Wiese, Diana Rancourt, Elizabeth G. Atkinson, Paola Giusti-Rodriguez, Jacey L. Anderberg, Latin American Trans-ancestry INitiative for OCD genomics, Brazilian Obsessive-Compulsive Spectrum Disorder Working Group, Jonathan S. Abramowitz, Victor R. Adorno, Cinthia Aguirre, Gilberto S. Alves, Gustavo S. Alves, NaEshia Ancalade, Alejandro A. Arellano Espinosa, Paul D. Arnold, Daphne M. Ayton, Izabela G. Barbosa, Laura Marcela Barón Castano, Cynthia N. Barrera, María Celeste Berardo, Dayan Berrones, John R. Best, Tim B. Bigdeli, Christie L. Burton, Joseph D. Buxbaum, Jennifer L. Callahan, Maria Cecília B. Carneiro, Sandra L. Cepeda, Evelyn Chazelle, Jessica M. Chire, Macarena Churruca Munoz, Pamela Claisse Quiroz, Journa Cobite, Jonathan S. Comer, Daniel L. Costa, Jennifer Crosbie, Victor O. Cruz, Guillermo Dager, Luisa F. Daza, Anabel de la Rosa-Gómez, Daniela del Río, Fernanda Z. Delage, Carolina B. Dreher, Lucila Fay, Tomas Fazio, Ygor A. Ferrão, Gabriela M. Ferreira, Edith G. Figueroa, Leonardo F. Fontenelle, Diego A. Forero, Daniele T. H. Fragoso, Bharathi S. Gadad, Sheldon R. Garrison, Andres González, Laura D. Gonzalez, Marco A. González, Polaris Gonzalez-Barrios, Wayne K. Goodman, Dorothy E. Grice, Jerry Guintivano, Daniel G. Guttfreund, Andrew G. Guzick, Matthew W. Halvorsen, Joseph D. Hovey, Hailiang Huang, Jonathan Irreño-Sotomonte, Reinhard Janssen-Aguilar, Matias Jensen, Alexandra Z. Jimenez Reynolds, Joali Alexandra Juárez Lujambio, Nasim Khalfe, Madison A. Knutsen, Caleb Lack, Nuria Lanzagorta, Monicke O. Lima, Melanie O. Longhurst, David A. Lozada Martinez, Elba S. Luna, Andrea H. Marques, Molly S. Martinez, Maria de Los Angeles Matos, Caitlyn E. Maye, Joseph F. McGuire, Gabriela Menezes, Charlene Minaya, Tomás Miño, Sara M. Mithani, Circe Montes de Oca, Alonso Morales-Rivero, Maria E. Moreira-de-Oliveira, Olivia J. Morris, Sandra I. Muñoz, Zainab Naqqash, Ambar A. Núñez Bracho, Belinda E. Núñez Bracho, Maria Corina Ochoa Rojas, Luis A. Olavarria Castaman, Trinidad Olivos Balmaceda, Iliana Ortega, Darpan I. Patel, Ainsley K. Patrick, Mariel Paz y Mino, Jose L. Perales Orellana, Bárbara Perdigão Stumpf, Tamara Peregrina, Tania Pérez Duarte, Kelly L. Piacsek, Maritza Placencia, María Belén Prieto, Lucas C. Quarantini, Yana Quarantini-Alvim, Renato T. Ramos, Iaroslava C. Ramos, Vanessa R. Ramos, Kesley A. Ramsey, Elise V. Ray, Margaret A. Richter, Bradley C. Riemann, Juan C. Rivas, Maria C. Rosario, Camilo J. Ruggero, Angel A. Ruiz-Chow, Alejandra Ruiz-Velasco, Melisa N. Sagarnaga, Aline S. Sampaio, Leonardo C. Saraiva, Russell J. Schachar, Sophie C. Schneider, Ethan J. Schweissing, Laura D. Seligman, Roseli G. Shavitt, Keaton J. Soileau, S. Evelyn Stewart, Shaina B. Storch, Emily R. Strouphauer, Vissente Tapia Cuevas, Kiara R. Timpano, Beatriz Treviño-de la Garza, Alexie Vallejo-Silva, Javier Vargas-Medrano, María I. Vásquez, Guadalupe Vidal Martinez, Saira A. Weinzimmer, Mauricio A. Yanez, Gwyneth Zai, Lina M. Zapata-Restrepo, Luz M. Zappa, Raquel M. Zepeda-Burgos, Anthony W. Zoghbi, Euripedes C. Miguel, Carolyn I. Rodriguez, Mayra C. Martinez Mallen, Pablo R. Moya, Tania Borda, María Beatriz Moyano, Manuel Mattheisen, Stacey Pereira, Gabriel Lázaro-Muñoz, Karen G. Martinez-Gonzalez, Michele T. Pato, Humberto Nicolini, Eric A. Storch
{"title":"拉丁美洲跨祖先强迫症基因组学研究(LATINO):研究方案。","authors":"James J. Crowley, Carolina Cappi, Marcos E. Ochoa-Panaifo, Renee M. Frederick, Minjee Kook, Andrew D. Wiese, Diana Rancourt, Elizabeth G. Atkinson, Paola Giusti-Rodriguez, Jacey L. Anderberg, Latin American Trans-ancestry INitiative for OCD genomics, Brazilian Obsessive-Compulsive Spectrum Disorder Working Group, Jonathan S. Abramowitz, Victor R. Adorno, Cinthia Aguirre, Gilberto S. Alves, Gustavo S. Alves, NaEshia Ancalade, Alejandro A. Arellano Espinosa, Paul D. Arnold, Daphne M. Ayton, Izabela G. Barbosa, Laura Marcela Barón Castano, Cynthia N. Barrera, María Celeste Berardo, Dayan Berrones, John R. Best, Tim B. Bigdeli, Christie L. Burton, Joseph D. Buxbaum, Jennifer L. Callahan, Maria Cecília B. Carneiro, Sandra L. Cepeda, Evelyn Chazelle, Jessica M. Chire, Macarena Churruca Munoz, Pamela Claisse Quiroz, Journa Cobite, Jonathan S. Comer, Daniel L. Costa, Jennifer Crosbie, Victor O. Cruz, Guillermo Dager, Luisa F. Daza, Anabel de la Rosa-Gómez, Daniela del Río, Fernanda Z. Delage, Carolina B. Dreher, Lucila Fay, Tomas Fazio, Ygor A. Ferrão, Gabriela M. Ferreira, Edith G. Figueroa, Leonardo F. Fontenelle, Diego A. Forero, Daniele T. H. Fragoso, Bharathi S. Gadad, Sheldon R. Garrison, Andres González, Laura D. Gonzalez, Marco A. González, Polaris Gonzalez-Barrios, Wayne K. Goodman, Dorothy E. Grice, Jerry Guintivano, Daniel G. Guttfreund, Andrew G. Guzick, Matthew W. Halvorsen, Joseph D. Hovey, Hailiang Huang, Jonathan Irreño-Sotomonte, Reinhard Janssen-Aguilar, Matias Jensen, Alexandra Z. Jimenez Reynolds, Joali Alexandra Juárez Lujambio, Nasim Khalfe, Madison A. Knutsen, Caleb Lack, Nuria Lanzagorta, Monicke O. Lima, Melanie O. Longhurst, David A. Lozada Martinez, Elba S. Luna, Andrea H. Marques, Molly S. Martinez, Maria de Los Angeles Matos, Caitlyn E. Maye, Joseph F. McGuire, Gabriela Menezes, Charlene Minaya, Tomás Miño, Sara M. Mithani, Circe Montes de Oca, Alonso Morales-Rivero, Maria E. Moreira-de-Oliveira, Olivia J. Morris, Sandra I. Muñoz, Zainab Naqqash, Ambar A. Núñez Bracho, Belinda E. Núñez Bracho, Maria Corina Ochoa Rojas, Luis A. Olavarria Castaman, Trinidad Olivos Balmaceda, Iliana Ortega, Darpan I. Patel, Ainsley K. Patrick, Mariel Paz y Mino, Jose L. Perales Orellana, Bárbara Perdigão Stumpf, Tamara Peregrina, Tania Pérez Duarte, Kelly L. Piacsek, Maritza Placencia, María Belén Prieto, Lucas C. Quarantini, Yana Quarantini-Alvim, Renato T. Ramos, Iaroslava C. Ramos, Vanessa R. Ramos, Kesley A. Ramsey, Elise V. Ray, Margaret A. Richter, Bradley C. Riemann, Juan C. Rivas, Maria C. Rosario, Camilo J. Ruggero, Angel A. Ruiz-Chow, Alejandra Ruiz-Velasco, Melisa N. Sagarnaga, Aline S. Sampaio, Leonardo C. Saraiva, Russell J. Schachar, Sophie C. Schneider, Ethan J. Schweissing, Laura D. Seligman, Roseli G. Shavitt, Keaton J. Soileau, S. Evelyn Stewart, Shaina B. Storch, Emily R. Strouphauer, Vissente Tapia Cuevas, Kiara R. Timpano, Beatriz Treviño-de la Garza, Alexie Vallejo-Silva, Javier Vargas-Medrano, María I. Vásquez, Guadalupe Vidal Martinez, Saira A. Weinzimmer, Mauricio A. Yanez, Gwyneth Zai, Lina M. Zapata-Restrepo, Luz M. Zappa, Raquel M. Zepeda-Burgos, Anthony W. Zoghbi, Euripedes C. Miguel, Carolyn I. Rodriguez, Mayra C. Martinez Mallen, Pablo R. Moya, Tania Borda, María Beatriz Moyano, Manuel Mattheisen, Stacey Pereira, Gabriel Lázaro-Muñoz, Karen G. Martinez-Gonzalez, Michele T. Pato, Humberto Nicolini, Eric A. Storch","doi":"10.1002/ajmg.b.32962","DOIUrl":null,"url":null,"abstract":"<p>Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.</p>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.32962","citationCount":"0","resultStr":"{\"title\":\"Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol\",\"authors\":\"James J. Crowley, Carolina Cappi, Marcos E. Ochoa-Panaifo, Renee M. Frederick, Minjee Kook, Andrew D. Wiese, Diana Rancourt, Elizabeth G. Atkinson, Paola Giusti-Rodriguez, Jacey L. Anderberg, Latin American Trans-ancestry INitiative for OCD genomics, Brazilian Obsessive-Compulsive Spectrum Disorder Working Group, Jonathan S. Abramowitz, Victor R. Adorno, Cinthia Aguirre, Gilberto S. Alves, Gustavo S. Alves, NaEshia Ancalade, Alejandro A. Arellano Espinosa, Paul D. Arnold, Daphne M. Ayton, Izabela G. Barbosa, Laura Marcela Barón Castano, Cynthia N. Barrera, María Celeste Berardo, Dayan Berrones, John R. Best, Tim B. Bigdeli, Christie L. Burton, Joseph D. Buxbaum, Jennifer L. Callahan, Maria Cecília B. Carneiro, Sandra L. Cepeda, Evelyn Chazelle, Jessica M. Chire, Macarena Churruca Munoz, Pamela Claisse Quiroz, Journa Cobite, Jonathan S. Comer, Daniel L. Costa, Jennifer Crosbie, Victor O. Cruz, Guillermo Dager, Luisa F. Daza, Anabel de la Rosa-Gómez, Daniela del Río, Fernanda Z. Delage, Carolina B. Dreher, Lucila Fay, Tomas Fazio, Ygor A. Ferrão, Gabriela M. Ferreira, Edith G. Figueroa, Leonardo F. Fontenelle, Diego A. Forero, Daniele T. H. Fragoso, Bharathi S. Gadad, Sheldon R. Garrison, Andres González, Laura D. Gonzalez, Marco A. González, Polaris Gonzalez-Barrios, Wayne K. Goodman, Dorothy E. Grice, Jerry Guintivano, Daniel G. Guttfreund, Andrew G. 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Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.
期刊介绍:
Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) , provides a forum for experimental and clinical investigations of the genetic mechanisms underlying neurologic and psychiatric disorders. It is a resource for novel genetics studies of the heritable nature of psychiatric and other nervous system disorders, characterized at the molecular, cellular or behavior levels. Neuropsychiatric Genetics publishes eight times per year.