用pyri伤寒和rhopalosiphi蚜的标准毒性试验建立剂量-反应关系

C. Grimm, H. Schmidli, F. Bakker, K. Brown, P. Campbell, M. Candolfi, P. Chapman, E. G. Harrison, M. Mead-Briggs, R. Schmuck, A. Ufer
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引用次数: 20

摘要

现有的标准化测试系统用于评估作物保护产品对非目标节肢动物pyri(Acari:Phytoseidae)和rhopalosiphi(膜翅目:Aphididae)的毒性,是旨在将产品的单一使用率与水对照进行比较的极限测试。评估了这些测试系统用于生成精细生态毒理学风险评估所需的剂量反应数据的适用性。在最坏情况下的实验室条件下以及在扩展的实验室条件中生成了作物保护产品对T.pyri和A.rhopalosiphi的剂量反应毒性数据,并使用标准Probit方法、逻辑回归、广义Probit分析和移动平均角法进行了分析,以计算LR50值(施用率杀伤50 % 暴露的生物体)。比较了模型的拟合、所得LR50值的精度和所需的最小重复次数。85年 % 在这些研究中,至少有一种统计方法取得了令人满意的结果。移动平均角法是应用最广泛的方法。结果表明,现有指南可用于进行剂量反应测试。讨论了风险评估的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of standard toxicity tests with Typhlodromus pyri and Aphidius rhopalosiphi to establish a dose-response relationship

The existing standardised test systems for assessing the toxicity of crop protection products to the non-target arthropods Typhlodromus pyri (Acari: Phytoseiidae) and Aphidius rhopalosiphi (Hymenoptera: Aphidiidae) are limit tests designed to compare a single-use rate of the product with a water control. The suitability of these test systems for generating dose-response data as required for refined ecotoxicological risk assessment was evaluated. Data on dose-response toxicity of crop protection products to T. pyri and A. rhopalosiphi were generated under worst-case laboratory and to T. pyri under extended laboratory conditions and analysed using the standard Probit method, a logistic regression, a generalised Probit analysis, and the moving average-angle method in order to calculate the LR50-values (application rate killing 50 % of the exposed organisms). The fit of the models, the precision of the resulting LR50 values, and the required minimum number of replicates were compared. In 85 % of the studies, at least one of the statistical methods led to satisfactory results. The moving average-angle method was the most widely applicable method. The results show that the existing guidelines can be used to perform dose-response tests. Implications for risk assessment are discussed.

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