{"title":"一类新的焦磷酸己烯基三萜的发现与分析","authors":"Dan Hu","doi":"10.1016/j.engmic.2022.100035","DOIUrl":null,"url":null,"abstract":"<div><p>Triterpenes are derived from squalene or oxidosqualene. However, a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered, formed by a new family of chimeric class I triterpene synthases. The cyclization mechanisms of triterpenes were elucidated by isotopic labeling and protein structural analyses, which helps understand the biosynthesis of triterpenes in nature.</p></div>","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667370322000261/pdfft?md5=c826781e7a1fc24a2cab8717beaca2ee&pid=1-s2.0-S2667370322000261-main.pdf","citationCount":"1","resultStr":"{\"title\":\"Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate\",\"authors\":\"Dan Hu\",\"doi\":\"10.1016/j.engmic.2022.100035\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Triterpenes are derived from squalene or oxidosqualene. However, a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered, formed by a new family of chimeric class I triterpene synthases. The cyclization mechanisms of triterpenes were elucidated by isotopic labeling and protein structural analyses, which helps understand the biosynthesis of triterpenes in nature.</p></div>\",\"PeriodicalId\":100478,\"journal\":{\"name\":\"Engineering Microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667370322000261/pdfft?md5=c826781e7a1fc24a2cab8717beaca2ee&pid=1-s2.0-S2667370322000261-main.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Engineering Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667370322000261\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Engineering Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667370322000261","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate
Triterpenes are derived from squalene or oxidosqualene. However, a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered, formed by a new family of chimeric class I triterpene synthases. The cyclization mechanisms of triterpenes were elucidated by isotopic labeling and protein structural analyses, which helps understand the biosynthesis of triterpenes in nature.
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