Wenzhen Li, Xiaobing Feng, Haozhe Zhang, Yi-Xin Wang, Qiang Zeng, Chong Liu, Victor W. Zhong, Dongming Wang
{"title":"中国成年人轮班工作与氧化应激和空腹血糖水平改变的关系","authors":"Wenzhen Li, Xiaobing Feng, Haozhe Zhang, Yi-Xin Wang, Qiang Zeng, Chong Liu, Victor W. Zhong, Dongming Wang","doi":"10.1002/oby.23845","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study aimed to assess the association of shift work with blood glucose and the mediating role of oxidative stress.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Fasting plasma glucose (FPG) and urinary concentrations of oxidative stress biomarkers (8-hydroxy-2'-deoxyguanosine [8-OHdG], 4-hydroxy-2-nonenal-mercapturic acid, and 8-iso-prostaglandin <i>F</i><sub>2α</sub> [8-isoPGF<sub>2α</sub>]) were measured among 831 participants.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Positive dose-response relationships among shift work duration, FPG (<i>p</i><sub>trend</sub> < 0.001), and abnormal glucose regulation (AGR; <i>p</i><sub>trend</sub> = 0.035) were found. Compared with participants without shift work, three-shift work was associated with a higher level of FPG (percentage change: 6.49%, 95% CI: 4.21%–8.83%) and a higher prevalence of impaired fasting glucose (odds ratio: 1.886, 95% CI: 1.114–3.192) and AGR (odds ratio: 1.929, 95% CI: 1.197–3.111). A dose-response relationship was found between shift work duration and 8-OHdG (<i>p</i><sub>trend</sub> = 0.002) and 8-isoPGF<sub>2α</sub> (<i>p</i><sub>trend</sub> = 0.019). Urinary 8-OHdG and 8-isoPGF<sub>2α</sub> partially mediated the association between shift work duration and FPG levels and the prevalence of impaired fasting glucose and AGR, with mediating proportions ranging from 4.77% to 20.76%.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>These findings suggest that shift work is positively associated with blood glucose, and the association is partially mediated by oxidative stress.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"31 10","pages":"2505-2514"},"PeriodicalIF":4.2000,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.23845","citationCount":"0","resultStr":"{\"title\":\"Association of shift work with oxidative stress and alteration of fasting plasma glucose level in Chinese adults\",\"authors\":\"Wenzhen Li, Xiaobing Feng, Haozhe Zhang, Yi-Xin Wang, Qiang Zeng, Chong Liu, Victor W. Zhong, Dongming Wang\",\"doi\":\"10.1002/oby.23845\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This study aimed to assess the association of shift work with blood glucose and the mediating role of oxidative stress.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Fasting plasma glucose (FPG) and urinary concentrations of oxidative stress biomarkers (8-hydroxy-2'-deoxyguanosine [8-OHdG], 4-hydroxy-2-nonenal-mercapturic acid, and 8-iso-prostaglandin <i>F</i><sub>2α</sub> [8-isoPGF<sub>2α</sub>]) were measured among 831 participants.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Positive dose-response relationships among shift work duration, FPG (<i>p</i><sub>trend</sub> < 0.001), and abnormal glucose regulation (AGR; <i>p</i><sub>trend</sub> = 0.035) were found. Compared with participants without shift work, three-shift work was associated with a higher level of FPG (percentage change: 6.49%, 95% CI: 4.21%–8.83%) and a higher prevalence of impaired fasting glucose (odds ratio: 1.886, 95% CI: 1.114–3.192) and AGR (odds ratio: 1.929, 95% CI: 1.197–3.111). A dose-response relationship was found between shift work duration and 8-OHdG (<i>p</i><sub>trend</sub> = 0.002) and 8-isoPGF<sub>2α</sub> (<i>p</i><sub>trend</sub> = 0.019). Urinary 8-OHdG and 8-isoPGF<sub>2α</sub> partially mediated the association between shift work duration and FPG levels and the prevalence of impaired fasting glucose and AGR, with mediating proportions ranging from 4.77% to 20.76%.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>These findings suggest that shift work is positively associated with blood glucose, and the association is partially mediated by oxidative stress.</p>\\n </section>\\n </div>\",\"PeriodicalId\":215,\"journal\":{\"name\":\"Obesity\",\"volume\":\"31 10\",\"pages\":\"2505-2514\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2023-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.23845\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/oby.23845\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.23845","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association of shift work with oxidative stress and alteration of fasting plasma glucose level in Chinese adults
Objective
This study aimed to assess the association of shift work with blood glucose and the mediating role of oxidative stress.
Methods
Fasting plasma glucose (FPG) and urinary concentrations of oxidative stress biomarkers (8-hydroxy-2'-deoxyguanosine [8-OHdG], 4-hydroxy-2-nonenal-mercapturic acid, and 8-iso-prostaglandin F2α [8-isoPGF2α]) were measured among 831 participants.
Results
Positive dose-response relationships among shift work duration, FPG (ptrend < 0.001), and abnormal glucose regulation (AGR; ptrend = 0.035) were found. Compared with participants without shift work, three-shift work was associated with a higher level of FPG (percentage change: 6.49%, 95% CI: 4.21%–8.83%) and a higher prevalence of impaired fasting glucose (odds ratio: 1.886, 95% CI: 1.114–3.192) and AGR (odds ratio: 1.929, 95% CI: 1.197–3.111). A dose-response relationship was found between shift work duration and 8-OHdG (ptrend = 0.002) and 8-isoPGF2α (ptrend = 0.019). Urinary 8-OHdG and 8-isoPGF2α partially mediated the association between shift work duration and FPG levels and the prevalence of impaired fasting glucose and AGR, with mediating proportions ranging from 4.77% to 20.76%.
Conclusions
These findings suggest that shift work is positively associated with blood glucose, and the association is partially mediated by oxidative stress.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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