木筏参与神经系统疾病

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY

Neurologia Pub Date : 2023-11-01 DOI:10.1016/j.nrl.2021.01.008

U. Meza, C. Romero-Méndez, S. Sánchez-Armáss, A.A. Rodríguez-Menchaca

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引用次数: 0

摘要

引言Rafts是一种功能结构的细胞膜纳米结构域。它们通过聚集在专门的信号结构域内，有助于解释在信号伴侣的低生理膜浓度下信号转导的效率。发展在这篇文章中，我们回顾了目前的膜筏模型及其在神经系统中的生理病理相关性，包括它们在帕金森病、阿尔茨海默病和亨廷顿舞蹈症中的作用。结论Rafts破坏/功能障碍与多种神经系统疾病有关。因此，有人认为，保存膜筏可能是预防或延缓几种疾病中神经元功能障碍的一种策略。

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Participación de rafts en enfermedades neurológicas

Introduction

Rafts are function-structural cell membrane nano-domains. They contribute to explain the efficiency of signal transduction at the low physiological membrane concentrations of the signaling partners by their clustering inside specialized signaling domains.

Development

In this article, we review the current model of the membrane rafts and their physio-pathological relevance in the nervous system, including their role in Parkinson, Alzheimer, and Huntington diseases.

Conclusions

Rafts disruption/dysfunction has been shown to relate diverse neurological diseases. Therefore, it has been suggested that preservation of membrane rafts may represent a strategy to prevent or delay neuronal dysfunctions in several diseases.

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.