C.G. Wakfie-Corieh , F. Ferrando-Castagnetto , M. García-Esquinas , M.N. Cabrera-Martín , C. Rodríguez Rey , A. Ortega Candil , R.M. Couto Caro , J.L. Carreras Delgado
{"title":"18F-FDG PET/CT研究中偶然发现提示COVID-19肺炎患者肺结构改变的代谢特征。大流行期间获得的多模态图像的病理生理学视角","authors":"C.G. Wakfie-Corieh , F. Ferrando-Castagnetto , M. García-Esquinas , M.N. Cabrera-Martín , C. Rodríguez Rey , A. Ortega Candil , R.M. Couto Caro , J.L. Carreras Delgado","doi":"10.1016/j.remn.2023.07.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the metabolic uptake of different tomographic signs observed in patients with incidental structural findings suggestive of COVID-19 pneumonia through <sup>18</sup>F-FDG PET/CT.</p></div><div><h3>Material and methods</h3><p>We retrospectively analyzed 596 PET/CT studies performed from February 21, 2020 to April 17, 2020. After excluding 37 scans (non-<sup>18</sup>F-FDG PET tracers and brain studies), we analyzed the metabolic activity of several structural changes integrated in the CO-RADS score using the SUVmax of multimodal studies with <sup>18</sup>F-FDG.</p></div><div><h3>Results</h3><p>Forty-three patients with <sup>18</sup>F-FDG PET/CT findings suggestive of COVID-19 pneumonia were included (mean age: 68<!--> <!-->±<!--> <!-->12.3 years, 22 male). SUVmax values were higher in patients with CO-RADS categories 5–6 than in those with lower CO-RADS categories (6.1<!--> <!-->±<!--> <!-->3.0 vs. 3.6<!--> <!-->±<!--> <!-->2.1, <em>p</em> <!-->=<!--> <!-->0.004). In patients with CO-RADS 5–6, ground-glass opacities, bilaterality and consolidations exhibited higher SUVmax values (<em>p</em>-values of 0.01, 0.02 and 0.01, respectively). Patchy distribution and crazy paving pattern were also associated with higher SUVmax (<em>p</em>-values of 0.002 and 0.01). After multivariate analysis, SUVmax was significantly associated with a positive structural diagnosis of COVID-19 pneumonia (odds ratio<!--> <!-->=<!--> <!-->0.63, 95% confidence interval<!--> <!-->=<!--> <!-->0.41–0.90; <em>p</em> <!-->=<!--> <!-->0.02). The ROC curve of the regression model intended to confirm or rule out the structural diagnosis of COVID-19 pneumonia showed an AUC of 0.77 (standard error<!--> <!-->=<!--> <!-->0.072, <em>p</em> <!-->=<!--> <!-->0.003).</p></div><div><h3>Conclusions</h3><p>In those patients referred for standard oncologic and non-oncologic indications (43/559; 7.7%) during pandemic, imaging with <sup>18</sup>F-FDG PET/CT is a useful tool during incidental detection of COVID-19 pneumonia. Several CT findings characteristic of COVID-19 pneumonia, specifically those included in diagnostic CO-RADS scores (5–6), were associated with higher SUVmax values.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 6","pages":"Pages 380-387"},"PeriodicalIF":1.6000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Caracterización metabólica de los cambios pulmonares estructurales en pacientes con hallazgos incidentales sugestivos de neumonía por COVID-19 en estudios 18F-FDG PET/CT. Perspectivas fisiopatológicas de imágenes multimodales obtenidas durante la pandemia\",\"authors\":\"C.G. Wakfie-Corieh , F. Ferrando-Castagnetto , M. García-Esquinas , M.N. Cabrera-Martín , C. Rodríguez Rey , A. Ortega Candil , R.M. Couto Caro , J.L. Carreras Delgado\",\"doi\":\"10.1016/j.remn.2023.07.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>To evaluate the metabolic uptake of different tomographic signs observed in patients with incidental structural findings suggestive of COVID-19 pneumonia through <sup>18</sup>F-FDG PET/CT.</p></div><div><h3>Material and methods</h3><p>We retrospectively analyzed 596 PET/CT studies performed from February 21, 2020 to April 17, 2020. After excluding 37 scans (non-<sup>18</sup>F-FDG PET tracers and brain studies), we analyzed the metabolic activity of several structural changes integrated in the CO-RADS score using the SUVmax of multimodal studies with <sup>18</sup>F-FDG.</p></div><div><h3>Results</h3><p>Forty-three patients with <sup>18</sup>F-FDG PET/CT findings suggestive of COVID-19 pneumonia were included (mean age: 68<!--> <!-->±<!--> <!-->12.3 years, 22 male). SUVmax values were higher in patients with CO-RADS categories 5–6 than in those with lower CO-RADS categories (6.1<!--> <!-->±<!--> <!-->3.0 vs. 3.6<!--> <!-->±<!--> <!-->2.1, <em>p</em> <!-->=<!--> <!-->0.004). In patients with CO-RADS 5–6, ground-glass opacities, bilaterality and consolidations exhibited higher SUVmax values (<em>p</em>-values of 0.01, 0.02 and 0.01, respectively). Patchy distribution and crazy paving pattern were also associated with higher SUVmax (<em>p</em>-values of 0.002 and 0.01). After multivariate analysis, SUVmax was significantly associated with a positive structural diagnosis of COVID-19 pneumonia (odds ratio<!--> <!-->=<!--> <!-->0.63, 95% confidence interval<!--> <!-->=<!--> <!-->0.41–0.90; <em>p</em> <!-->=<!--> <!-->0.02). The ROC curve of the regression model intended to confirm or rule out the structural diagnosis of COVID-19 pneumonia showed an AUC of 0.77 (standard error<!--> <!-->=<!--> <!-->0.072, <em>p</em> <!-->=<!--> <!-->0.003).</p></div><div><h3>Conclusions</h3><p>In those patients referred for standard oncologic and non-oncologic indications (43/559; 7.7%) during pandemic, imaging with <sup>18</sup>F-FDG PET/CT is a useful tool during incidental detection of COVID-19 pneumonia. Several CT findings characteristic of COVID-19 pneumonia, specifically those included in diagnostic CO-RADS scores (5–6), were associated with higher SUVmax values.</p></div>\",\"PeriodicalId\":48986,\"journal\":{\"name\":\"Revista Espanola De Medicina Nuclear E Imagen Molecular\",\"volume\":\"42 6\",\"pages\":\"Pages 380-387\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Espanola De Medicina Nuclear E Imagen Molecular\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2253654X23000823\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Espanola De Medicina Nuclear E Imagen Molecular","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2253654X23000823","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Caracterización metabólica de los cambios pulmonares estructurales en pacientes con hallazgos incidentales sugestivos de neumonía por COVID-19 en estudios 18F-FDG PET/CT. Perspectivas fisiopatológicas de imágenes multimodales obtenidas durante la pandemia
Purpose
To evaluate the metabolic uptake of different tomographic signs observed in patients with incidental structural findings suggestive of COVID-19 pneumonia through 18F-FDG PET/CT.
Material and methods
We retrospectively analyzed 596 PET/CT studies performed from February 21, 2020 to April 17, 2020. After excluding 37 scans (non-18F-FDG PET tracers and brain studies), we analyzed the metabolic activity of several structural changes integrated in the CO-RADS score using the SUVmax of multimodal studies with 18F-FDG.
Results
Forty-three patients with 18F-FDG PET/CT findings suggestive of COVID-19 pneumonia were included (mean age: 68 ± 12.3 years, 22 male). SUVmax values were higher in patients with CO-RADS categories 5–6 than in those with lower CO-RADS categories (6.1 ± 3.0 vs. 3.6 ± 2.1, p = 0.004). In patients with CO-RADS 5–6, ground-glass opacities, bilaterality and consolidations exhibited higher SUVmax values (p-values of 0.01, 0.02 and 0.01, respectively). Patchy distribution and crazy paving pattern were also associated with higher SUVmax (p-values of 0.002 and 0.01). After multivariate analysis, SUVmax was significantly associated with a positive structural diagnosis of COVID-19 pneumonia (odds ratio = 0.63, 95% confidence interval = 0.41–0.90; p = 0.02). The ROC curve of the regression model intended to confirm or rule out the structural diagnosis of COVID-19 pneumonia showed an AUC of 0.77 (standard error = 0.072, p = 0.003).
Conclusions
In those patients referred for standard oncologic and non-oncologic indications (43/559; 7.7%) during pandemic, imaging with 18F-FDG PET/CT is a useful tool during incidental detection of COVID-19 pneumonia. Several CT findings characteristic of COVID-19 pneumonia, specifically those included in diagnostic CO-RADS scores (5–6), were associated with higher SUVmax values.
期刊介绍：
The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members.
The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles.
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