Louise Miglianico , Divi Cornec , Valérie Devauchelle-Pensec , Sofian Berrouiguet , Michel Walter , Florian Stéphan
{"title":"原发性Sjögren综合征中与抑郁、焦虑和/或疲劳相关的炎症生物标志物——一项系统综述","authors":"Louise Miglianico , Divi Cornec , Valérie Devauchelle-Pensec , Sofian Berrouiguet , Michel Walter , Florian Stéphan","doi":"10.1016/j.ejpsy.2022.04.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Fatigue, depression, and anxiety are common burdens present in primary Sjögren's syndrome patients. Those symptoms have all been linked to inflammatory dysregulations. To explore the link between inflammatory biomarkers and fatigue, depression, and anxiety in pSS patients, we aim to do a </span>systematic literature review.</p></div><div><h3>Methods</h3><p>The systematic review protocol and data extraction forms were designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our protocol has been registered on Prospero (ID CRD42020161952). The Cochrane Library, PubMed, Scopus, and PsycInfo were used, from inception to December 2019.</p></div><div><h3>Results</h3><p>The literature search initially identified 445 articles. Finally, 12 articles were included in this systematic review. The population in studies was quite similar with mainly middle-aged women. Dates of publication extended from 2008 to 2019. Different scales were used to measure fatigue, depression, and/or anxiety. Measured inflammatory biomarkers were very diverse across studies. In consequence, results in the different included studies were disparate. Only one study explored the link between depression/anxiety and inflammatory markers: patients with depression and/or anxiety were compared to pSS patients.</p></div><div><h3>Conclusion</h3><p>Even if the association between fatigue, depression, and/or anxiety with inflammatory markers in pSS is of interest, there are a lot of discrepancies. Sickness behavior and IFN<span> pathways seem to be important in the inflammatory physiopathology of fatigue in pSS, and interest in depression. It also appears crucial to standardize clinical scales, inflammatory blood, and CSF tests in pSS patients to allow better generalization.</span></p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inflammatory biomarkers associated with depression, anxiety, and/or fatigue in primary Sjögren's syndrome – a systematic review\",\"authors\":\"Louise Miglianico , Divi Cornec , Valérie Devauchelle-Pensec , Sofian Berrouiguet , Michel Walter , Florian Stéphan\",\"doi\":\"10.1016/j.ejpsy.2022.04.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and objectives</h3><p><span>Fatigue, depression, and anxiety are common burdens present in primary Sjögren's syndrome patients. Those symptoms have all been linked to inflammatory dysregulations. To explore the link between inflammatory biomarkers and fatigue, depression, and anxiety in pSS patients, we aim to do a </span>systematic literature review.</p></div><div><h3>Methods</h3><p>The systematic review protocol and data extraction forms were designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our protocol has been registered on Prospero (ID CRD42020161952). The Cochrane Library, PubMed, Scopus, and PsycInfo were used, from inception to December 2019.</p></div><div><h3>Results</h3><p>The literature search initially identified 445 articles. Finally, 12 articles were included in this systematic review. The population in studies was quite similar with mainly middle-aged women. Dates of publication extended from 2008 to 2019. Different scales were used to measure fatigue, depression, and/or anxiety. Measured inflammatory biomarkers were very diverse across studies. In consequence, results in the different included studies were disparate. Only one study explored the link between depression/anxiety and inflammatory markers: patients with depression and/or anxiety were compared to pSS patients.</p></div><div><h3>Conclusion</h3><p>Even if the association between fatigue, depression, and/or anxiety with inflammatory markers in pSS is of interest, there are a lot of discrepancies. Sickness behavior and IFN<span> pathways seem to be important in the inflammatory physiopathology of fatigue in pSS, and interest in depression. It also appears crucial to standardize clinical scales, inflammatory blood, and CSF tests in pSS patients to allow better generalization.</span></p></div>\",\"PeriodicalId\":12045,\"journal\":{\"name\":\"European Journal of Psychiatry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2022-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0213616322000325\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0213616322000325","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Inflammatory biomarkers associated with depression, anxiety, and/or fatigue in primary Sjögren's syndrome – a systematic review
Background and objectives
Fatigue, depression, and anxiety are common burdens present in primary Sjögren's syndrome patients. Those symptoms have all been linked to inflammatory dysregulations. To explore the link between inflammatory biomarkers and fatigue, depression, and anxiety in pSS patients, we aim to do a systematic literature review.
Methods
The systematic review protocol and data extraction forms were designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our protocol has been registered on Prospero (ID CRD42020161952). The Cochrane Library, PubMed, Scopus, and PsycInfo were used, from inception to December 2019.
Results
The literature search initially identified 445 articles. Finally, 12 articles were included in this systematic review. The population in studies was quite similar with mainly middle-aged women. Dates of publication extended from 2008 to 2019. Different scales were used to measure fatigue, depression, and/or anxiety. Measured inflammatory biomarkers were very diverse across studies. In consequence, results in the different included studies were disparate. Only one study explored the link between depression/anxiety and inflammatory markers: patients with depression and/or anxiety were compared to pSS patients.
Conclusion
Even if the association between fatigue, depression, and/or anxiety with inflammatory markers in pSS is of interest, there are a lot of discrepancies. Sickness behavior and IFN pathways seem to be important in the inflammatory physiopathology of fatigue in pSS, and interest in depression. It also appears crucial to standardize clinical scales, inflammatory blood, and CSF tests in pSS patients to allow better generalization.
期刊介绍:
The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.