原发性Sjögren综合征中与抑郁、焦虑和/或疲劳相关的炎症生物标志物——一项系统综述

IF 2.5 4区 医学 Q2 PSYCHIATRY
Louise Miglianico , Divi Cornec , Valérie Devauchelle-Pensec , Sofian Berrouiguet , Michel Walter , Florian Stéphan
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引用次数: 0

摘要

背景和目的疲劳、抑郁和焦虑是原发性干燥综合征患者常见的负担。这些症状都与炎症失调有关。为了探索炎症生物标志物与pSS患者疲劳、抑郁和焦虑之间的联系,我们旨在进行系统的文献综述。方法按照系统评价和荟萃分析的首选报告项目(PRISMA)设计系统评价方案和数据提取表。我们的协议已在Prospero上注册(ID CRD42020161952)。从成立到2019年12月,使用了Cochrane图书馆、PubMed、Scopus和PsycInfo。结果文献检索最初确定了445篇文章。最后,本系统综述共收录了12篇文章。研究中的人群非常相似,主要是中年女性。出版日期从2008年延长至2019年。使用不同的量表来测量疲劳、抑郁和/或焦虑。在不同的研究中,测量的炎症生物标志物非常多样化。因此,不同纳入研究的结果是不同的。只有一项研究探讨了抑郁/焦虑与炎症标志物之间的联系:将抑郁和/或焦虑患者与pSS患者进行比较。结论即使疲劳、抑郁和/或焦虑与pSS炎症标志物之间的关系是令人感兴趣的,但也存在很多差异。疾病行为和IFN途径似乎在pSS疲劳的炎症病理生理学和对抑郁症的兴趣中很重要。对pSS患者的临床量表、炎症性血液和CSF测试进行标准化似乎也至关重要,以便更好地进行概括。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory biomarkers associated with depression, anxiety, and/or fatigue in primary Sjögren's syndrome – a systematic review

Background and objectives

Fatigue, depression, and anxiety are common burdens present in primary Sjögren's syndrome patients. Those symptoms have all been linked to inflammatory dysregulations. To explore the link between inflammatory biomarkers and fatigue, depression, and anxiety in pSS patients, we aim to do a systematic literature review.

Methods

The systematic review protocol and data extraction forms were designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our protocol has been registered on Prospero (ID CRD42020161952). The Cochrane Library, PubMed, Scopus, and PsycInfo were used, from inception to December 2019.

Results

The literature search initially identified 445 articles. Finally, 12 articles were included in this systematic review. The population in studies was quite similar with mainly middle-aged women. Dates of publication extended from 2008 to 2019. Different scales were used to measure fatigue, depression, and/or anxiety. Measured inflammatory biomarkers were very diverse across studies. In consequence, results in the different included studies were disparate. Only one study explored the link between depression/anxiety and inflammatory markers: patients with depression and/or anxiety were compared to pSS patients.

Conclusion

Even if the association between fatigue, depression, and/or anxiety with inflammatory markers in pSS is of interest, there are a lot of discrepancies. Sickness behavior and IFN pathways seem to be important in the inflammatory physiopathology of fatigue in pSS, and interest in depression. It also appears crucial to standardize clinical scales, inflammatory blood, and CSF tests in pSS patients to allow better generalization.

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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
40
审稿时长
43 days
期刊介绍: The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
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