Tingting YIN , Zhijian CHEN , Zeyuan WEI , Yushu LU , Reheman AIKEBAIER , Yan CHEN
{"title":"用于靶向磁共振成像和药物递送的聚单宁酸铁仿生纳米颗粒","authors":"Tingting YIN , Zhijian CHEN , Zeyuan WEI , Yushu LU , Reheman AIKEBAIER , Yan CHEN","doi":"10.1016/j.cjac.2023.100331","DOIUrl":null,"url":null,"abstract":"<div><p>The artificial nanomaterials with surface modification are promising platform in targeted therapy, but the nanomaterials are easily tracked by the reticuloendothelial system (RES) before reaching the target sites. Here we report a biomimetic camouflage system, macrophage membrane (MM) coated iron-poly(tannic acid) nanoparticels (Fe-PTA NPs) for targeted drug delivery and magnetic resonance imaging (MRI). The MM inherits the surface protein profiles from macrophage (RAW 264.7 cells), which would escape from RES and target the homotypic cells. The anticancer drug doxorubicin (DOX) was loaded into MM-Fe-PTA NPs, and demonstrated pH-responsive release ability. In addition, the MM-Fe-PTA NPs can be used as <em>T</em><sub>1</sub>-weighted MRI contrast agents for targeted MRI. This cell membrane camouflage strategy has great potential and challenge for clinic targeted therapy.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 11","pages":"Article 100331"},"PeriodicalIF":1.2000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Iron-poly(tannic acid) biomimetic nanoparticles for targeted magnetic resonance imaging and drug delivery\",\"authors\":\"Tingting YIN , Zhijian CHEN , Zeyuan WEI , Yushu LU , Reheman AIKEBAIER , Yan CHEN\",\"doi\":\"10.1016/j.cjac.2023.100331\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The artificial nanomaterials with surface modification are promising platform in targeted therapy, but the nanomaterials are easily tracked by the reticuloendothelial system (RES) before reaching the target sites. Here we report a biomimetic camouflage system, macrophage membrane (MM) coated iron-poly(tannic acid) nanoparticels (Fe-PTA NPs) for targeted drug delivery and magnetic resonance imaging (MRI). The MM inherits the surface protein profiles from macrophage (RAW 264.7 cells), which would escape from RES and target the homotypic cells. The anticancer drug doxorubicin (DOX) was loaded into MM-Fe-PTA NPs, and demonstrated pH-responsive release ability. In addition, the MM-Fe-PTA NPs can be used as <em>T</em><sub>1</sub>-weighted MRI contrast agents for targeted MRI. This cell membrane camouflage strategy has great potential and challenge for clinic targeted therapy.</p></div>\",\"PeriodicalId\":277,\"journal\":{\"name\":\"Chinese Journal of Analytical Chemistry\",\"volume\":\"51 11\",\"pages\":\"Article 100331\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Analytical Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1872204023001056\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Analytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1872204023001056","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Iron-poly(tannic acid) biomimetic nanoparticles for targeted magnetic resonance imaging and drug delivery
The artificial nanomaterials with surface modification are promising platform in targeted therapy, but the nanomaterials are easily tracked by the reticuloendothelial system (RES) before reaching the target sites. Here we report a biomimetic camouflage system, macrophage membrane (MM) coated iron-poly(tannic acid) nanoparticels (Fe-PTA NPs) for targeted drug delivery and magnetic resonance imaging (MRI). The MM inherits the surface protein profiles from macrophage (RAW 264.7 cells), which would escape from RES and target the homotypic cells. The anticancer drug doxorubicin (DOX) was loaded into MM-Fe-PTA NPs, and demonstrated pH-responsive release ability. In addition, the MM-Fe-PTA NPs can be used as T1-weighted MRI contrast agents for targeted MRI. This cell membrane camouflage strategy has great potential and challenge for clinic targeted therapy.
期刊介绍：
Chinese Journal of Analytical Chemistry(CJAC) is an academic journal of analytical chemistry established in 1972 and sponsored by the Chinese Chemical Society and Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. Its objectives are to report the original scientific research achievements and review the recent development of analytical chemistry in all areas. The journal sets up 5 columns including Research Papers, Research Notes, Experimental Technique and Instrument, Review and Progress and Summary Accounts. The journal published monthly in Chinese language. A detailed abstract, keywords and the titles of figures and tables are provided in English, except column of Summary Accounts. Prof. Wang Erkang, an outstanding analytical chemist, academician of Chinese Academy of Sciences & Third World Academy of Sciences, holds the post of the Editor-in-chief.
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