通过对心肌细胞表观基因组进行代谢重新编程来再生心脏。

Cell metabolism Pub Date : 2023-11-07 DOI:10.1016/j.cmet.2023.10.007

Xiaoqiang Tang

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引用次数: 0

摘要

在哺乳动物的青春期，心肌细胞迅速退出细胞周期，成人心脏损伤后心脏再生受到限制。李等人最近的工作。《自然》杂志揭示，抑制脂肪酸氧化可以重新连接细胞代谢，并导致心肌细胞的表观遗传学重编程到未成熟状态，从而促进成年动物的心肌细胞周期重新进入和心脏再生。

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Regenerating the heart by metabolically reprogramming the cardiomyocyte epigenome.

In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration in adults is limited after cardiac injury. Recent work by Li et al. in Nature revealed that inhibition of fatty acid oxidation can rewire cell metabolism and lead to epigenetic reprogramming of cardiomyocytes to an immature state that facilitates cardiomyocyte cell-cycle reentry and heart regeneration in adult animals.

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Cell metabolism

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