Cell metabolism

Arginine rewires eIF4F translation initiation to overcome fever-induced CAR T cell dysfunction.

Pub Date : 2026-10-28 DOI: 10.1016/j.cmet.2026.10.001 Taisuke Kondo, Makoto Ando, Josquin Moraly, Justyn DuSold, Abdallah Abdelmaksoud, Hannah W Song, Lakshmi Balagopalan, Dongya Jia, Laetitia Racine, Andy D Tran, Sooraj Achar, Serifat O Adebola, Pedro Gonzalez-Menendez, John Buckley, Anjali Chandroth, Alka Dwivedi, Nikolaos Svoronos, Angela Su, Christopher D Chien, Alexander D Clark, Xiyuan Zhang, Bonnie Yates, King Chan, Stephen D Fox, Xia Xu, Nicholas P Restifo, Neeraja Syed, Michael C Kelly, Michael Kruhlak, Yuki Kagoya, Rémy Bosselut, Jack F Shern, Thorkell Andresson, Valérie Dardalhon, Craig J Thomas, Steven L Highfill, Nirali N Shah, Grégoire Altan-Bonnet, Naomi Taylor

Dynamic force sensing by bone delays aging and extends lifespan.

Pub Date : 2026-10-23 DOI: 10.1016/j.cmet.2026.09.020 Zhimin Zhang, Zhiqing Cai, Shencai Liu, Yun Chu, Zhengtao Jiang, Wuju Zhang, Yating Pan, Ying Lin, Xiaocui Wei, Jingting Chen, Junnan Huangfu, Bocheng Nan, Yibo Zhou, Le Hu, Wenquan Liang, Zhipeng Zou, Minjun Huang, Sheng Lu, Di Lu, Xiaochun Bai

UBT251, a novel triple GLP-1, GIP, and glucagon receptor agonist, in adults with overweight or obesity: A multicenter, randomized phase 2 trial.

Pub Date : 2026-10-08 DOI: 10.1016/j.cmet.2026.09.021 Zhiguang Zhou, Zhifeng Cheng, Ping Jin, Guoping Yang, Haifang Wang, Bimin Shi, Qijuan Dong, Xiaoxia Shi, Xiaoguang Shi, Hongyan Shu, Wenli Sun, Chongbing Huang, Shuping Zhao, Li Mao, Wei Wang, Ping Xiong, Xiaowen Chen, Junhang Tian, Haiyan Zhang, Tao Su, Liang Huang, Sofie Bay Simony, Thomas Holst-Hansen, Huiru Yan