迈向一个能够预测人群损伤结果的变形人体模型家族的第一步。

IF 1.7 4区 医学 Q4 BIOPHYSICS
Karl-Johan Larsson, Jonas Östh, Johan Iraeus, Bengt Pipkorn
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引用次数: 0

摘要

车辆碰撞中的伤害风险可能取决于乘员的特定因素。使用有限元人体模型(HBM)来表示乘员可变性的虚拟碰撞测试可以使车辆的开发提高所有乘员的安全性。在这项研究中,研究了通过元模型表示人口崩溃结果需要多少不同大小的HBM。肋骨骨折风险被用作乘员受伤结果的一个例子。代表定义人群范围内性别、身高和体重变异性的变形HBM用于计算正面和侧面碰撞中肋骨骨折风险的人群变异性。使用两种回归方法,二阶项正则化线性回归和高斯过程回归(GPR),对因乘员变异性导致的肋骨骨折风险进行元建模。通过研究作为训练数据函数的元模型预测性能,发现使用每种性别的25个人构建GPR元模型似乎足以对一般车祸场景中的人群肋骨骨折风险结果进行建模。此外,通过利用两起车祸中的已知结果,一种优化方法选择了两起车祸场景中具有代表性的人群结果的个体。优化结果表明,每个性别的5-7个个体足以创建预测性GPR元模型。优化方法可以扩展到更多的碰撞和车辆,可用于识别在未来工作中通常代表人群伤害结果的HBM家族。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A First Step Toward a Family of Morphed Human Body Models Enabling Prediction of Population Injury Outcomes.

The injury risk in a vehicle crash can depend on occupant specific factors. Virtual crash testing using finite element human body models (HBMs) to represent occupant variability can enable the development of vehicles with improved safety for all occupants. In this study, it was investigated how many HBMs of different sizes that are needed to represent a population crash outcome through a metamodel. Rib fracture risk was used as an example occupant injury outcome. Morphed HBMs representing variability in sex, height, and weight within defined population ranges were used to calculate population variability in rib fracture risk in a frontal and a side crash. Two regression methods, regularized linear regression with second-order terms and Gaussian process regression (GPR), were used to metamodel rib fracture risk due to occupant variability. By studying metamodel predictive performance as a function of training data, it was found that constructing GPR metamodels using 25 individuals of each sex appears sufficient to model the population rib fracture risk outcome in a general crash scenario. Further, by utilizing the known outcomes in the two crashes, an optimization method selected individuals representative for population outcomes across both crash scenarios. The optimization results showed that 5-7 individuals of each sex were sufficient to create predictive GPR metamodels. The optimization method can be extended for more crashes and vehicles, which can be used to identify a family of HBMs that are generally representative of population injury outcomes in future work.

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来源期刊
CiteScore
3.40
自引率
5.90%
发文量
169
审稿时长
4-8 weeks
期刊介绍: Artificial Organs and Prostheses; Bioinstrumentation and Measurements; Bioheat Transfer; Biomaterials; Biomechanics; Bioprocess Engineering; Cellular Mechanics; Design and Control of Biological Systems; Physiological Systems.
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