特应性皮炎与注意力缺陷/多动障碍和自闭症谱系障碍的相关性:一项系统综述和荟萃分析。

IF 3 3区 医学 Q2 DERMATOLOGY
Dermatology Pub Date : 2024-01-01 Epub Date: 2023-11-08 DOI:10.1159/000533366
Yu Cheng, Jing-Wun Lu, Jen-Hung Wang, Ching-Hui Loh, Tai-Li Chen
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引用次数: 0

摘要

背景:特应性皮炎(AD)与注意力缺陷/多动障碍(ADHD)和自闭症谱系障碍(ASD)在炎症和遗传学发病机制方面有相似之处。然而,关于AD与ADHD和/或ASD之间关系的证据还没有定论。本研究旨在系统地研究AD、ADHD和ASD之间关系的现有证据。方法:遵循流行病学观察研究的Meta分析指南。我们搜索了MEDLINE、Embase、Cochrane图书馆和Web of Science数据库,从它们各自的概念到2022年2月4日。纳入了提供AD患者ADHD和ASD的调整估计值和/或患病率的观察性研究。进行随机效应模型荟萃分析,以计算合并优势比(OR)和置信区间(CI)。根据AD的严重程度、年龄、地理位置和研究设计进行亚组分析。结果:总体而言,共有24项研究,71373639名受试者入选。我们的荟萃分析显示,AD与ADHD(合并OR为1.28;95%CI为1.18-1.40)和ASD(合并OR,1.87;95%CI,1.30-2.68)之间存在显著关联。亚组分析显示,在评估严重AD患者的研究以及关注学龄儿童和青少年的研究中,ADHD的关联最为突出。在AD患者中,ADHD的合并患病率为6.6%,ASD的患病率分别为1.6%。结论:迄今为止的证据表明,AD与ADHD和ASD有显著关联。精神病咨询和跨学科的方法将有利于AD患者出现提示ADHD或ASD的行为症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of Atopic Dermatitis with Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.

Background: Atopic dermatitis (AD) shares similarities with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) regarding pathogenesis involving neuroinflammation and genetics. Nevertheless, evidence on the associations of AD with ADHD and/or ASD is inconclusive. This study aimed to systematically examine the existing evidence on the associations between AD, ADHD, and ASD.

Methods: The Meta-Analysis of Observational Studies in Epidemiology guideline was followed. We searched MEDLINE, Embase, Cochrane Library, and Web of Science databases from their respective inceptions to March 4, 2022. Observational studies providing adjusted estimates and/or prevalences for ADHD and ASD in patients with AD were enrolled. A random-effects model meta-analysis was conducted to calculate pooled odds ratios (ORs) and confidence intervals (CIs). Subgroup analyses according to AD severity, age, geographic location, and study design were performed.

Results: Overall, a total of 24 studies with 71,373,639 subjects were enrolled. Our meta-analysis demonstrated significant associations of AD with ADHD (pooled OR: 1.28; 95% CI: 1.18-1.40) and ASD (pooled OR: 1.87; 95% CI: 1.30-2.68). Subgroup analyses revealed that the associations for ADHD were the most prominent in studies evaluating severe AD patients as well as in studies focusing on school-age children and adolescents. Among patients with AD, the pooled prevalence of ADHD was 6.6%, and the respective prevalence of ASD was 1.6%.

Conclusion: The evidence to date suggests significant associations of AD with ADHD and ASD. Psychiatric consultation and an interdisciplinary approach would benefit patients with AD presented with behavioral symptoms suggestive of ADHD or ASD.

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来源期刊
Dermatology
Dermatology 医学-皮肤病学
CiteScore
6.40
自引率
2.90%
发文量
71
审稿时长
1 months
期刊介绍: Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.
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