{"title":"伊朗十年来肺炎链球菌血清型患病率监测：系统综述和荟萃分析。","authors":"Setareh Mamishi, Babak Pourakbari, Abbas Bahador, Reihaneh Hosseinpour Sadeghi, Maryam Pourhajibagher","doi":"10.2174/0118715265265907231025111012","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is no comprehensive information about the circulating serotypes of Streptococcus pneumoniae in Iran in recent years. This study aimed to summarize information about the changes over a decade in the serotype prevalence of <i>S. pneumoniae</i> in Iran.</p><p><strong>Methods: </strong>We performed a comprehensive search in PubMed/Medline, Web of Science, Science Direct, and the Iranian Database, such as Magiran and SID, from January 2011 to February 2023. The systematic process, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), was carried out by two researchers who were both independent and calibrated. Statistical analyses were carried out using Comprehensive Meta-Analysis software. Identifying and measuring heterogeneity were done using I<sup>2</sup> and the chi-square test. Finally, Begg's rank correlation test was used in combination with a funnel plot to evaluate any possible publication bias.</p><p><strong>Results: </strong>The search returned 16 relevant results, with a total of 1575 isolates. Of those studies, eight studies reported the distribution of <i>S. pneumoniae</i> serotypes among patients, three studies among healthy individuals, and five studies among both groups. As the meta-analysis revealed, the most common serotypes were 23F (n = 299, 14.1% [95% CI: 9.7-19.9]; I<sup>2</sup> = 84.3%; P<0.001 for heterogeneity), 19F (n = 221, 13.4% [95% CI: 9.9-17.9; I<sup>2</sup> = 76.7%; P<0.001 for heterogeneity]), and 19A (n = 102, 8.7% [95% CI: 6.5-11.7; I<sup>2</sup> = 54.3%; P<0.001 for heterogeneity]). Moreover, Begg's test (P = 0.160, 0.173, and 0.176 for 23F, 19F, and 19A, respectively) showed no evidence of publication bias.</p><p><strong>Conclusion: </strong>Based on our pooled results, the majority of the serotypes of pneumococci in the Iranian population were 23F, 19F, and 19A, respectively, over the last decade. The findings can be valuable in selecting effective pneumococcal vaccine candidates and targeted antibiotics in Iranian patients.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e031123223116"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Monitoring Over a Decade in the Serotype Prevalence of <i>Streptococcus pneumoniae</i> in Iran: A Systematic Review and Meta-analysis.\",\"authors\":\"Setareh Mamishi, Babak Pourakbari, Abbas Bahador, Reihaneh Hosseinpour Sadeghi, Maryam Pourhajibagher\",\"doi\":\"10.2174/0118715265265907231025111012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is no comprehensive information about the circulating serotypes of Streptococcus pneumoniae in Iran in recent years. This study aimed to summarize information about the changes over a decade in the serotype prevalence of <i>S. pneumoniae</i> in Iran.</p><p><strong>Methods: </strong>We performed a comprehensive search in PubMed/Medline, Web of Science, Science Direct, and the Iranian Database, such as Magiran and SID, from January 2011 to February 2023. The systematic process, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), was carried out by two researchers who were both independent and calibrated. Statistical analyses were carried out using Comprehensive Meta-Analysis software. Identifying and measuring heterogeneity were done using I<sup>2</sup> and the chi-square test. Finally, Begg's rank correlation test was used in combination with a funnel plot to evaluate any possible publication bias.</p><p><strong>Results: </strong>The search returned 16 relevant results, with a total of 1575 isolates. Of those studies, eight studies reported the distribution of <i>S. pneumoniae</i> serotypes among patients, three studies among healthy individuals, and five studies among both groups. As the meta-analysis revealed, the most common serotypes were 23F (n = 299, 14.1% [95% CI: 9.7-19.9]; I<sup>2</sup> = 84.3%; P<0.001 for heterogeneity), 19F (n = 221, 13.4% [95% CI: 9.9-17.9; I<sup>2</sup> = 76.7%; P<0.001 for heterogeneity]), and 19A (n = 102, 8.7% [95% CI: 6.5-11.7; I<sup>2</sup> = 54.3%; P<0.001 for heterogeneity]). Moreover, Begg's test (P = 0.160, 0.173, and 0.176 for 23F, 19F, and 19A, respectively) showed no evidence of publication bias.</p><p><strong>Conclusion: </strong>Based on our pooled results, the majority of the serotypes of pneumococci in the Iranian population were 23F, 19F, and 19A, respectively, over the last decade. 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引用次数: 0
摘要
背景：近年来，伊朗没有关于肺炎链球菌循环血清型的全面信息。本研究旨在总结伊朗肺炎链球菌血清型流行率十年来的变化信息。方法：从2011年1月到2023年2月，我们在PubMed/Medline、Web of Science、Science Direct和伊朗数据库（如Magiran和SID）中进行了全面搜索。根据系统评价和荟萃分析的首选报告项目（PRISMA），系统过程由两名独立且经过校准的研究人员进行。使用综合荟萃分析软件进行统计分析。使用I2和卡方检验来识别和测量异质性。最后，Begg秩相关检验与漏斗图相结合，用于评估任何可能的发表偏倚。结果：检索得到16个相关结果，共1575个分离株。在这些研究中，8项研究报告了肺炎链球菌血清型在患者中的分布，3项研究在健康个体中，5项研究在两组中。正如荟萃分析所揭示的，最常见的血清型为23F（n=299，14.1%[95%CI:9.7-19.9]；I2=84.3%；P结论：根据我们的汇总结果，在过去十年中，伊朗人群中大多数肺炎球菌血清型分别为23F、19F和19A。这些发现对伊朗患者选择有效的肺炎球菌候选疫苗和靶向抗生素有价值。
Monitoring Over a Decade in the Serotype Prevalence of Streptococcus pneumoniae in Iran: A Systematic Review and Meta-analysis.
Background: There is no comprehensive information about the circulating serotypes of Streptococcus pneumoniae in Iran in recent years. This study aimed to summarize information about the changes over a decade in the serotype prevalence of S. pneumoniae in Iran.
Methods: We performed a comprehensive search in PubMed/Medline, Web of Science, Science Direct, and the Iranian Database, such as Magiran and SID, from January 2011 to February 2023. The systematic process, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), was carried out by two researchers who were both independent and calibrated. Statistical analyses were carried out using Comprehensive Meta-Analysis software. Identifying and measuring heterogeneity were done using I2 and the chi-square test. Finally, Begg's rank correlation test was used in combination with a funnel plot to evaluate any possible publication bias.
Results: The search returned 16 relevant results, with a total of 1575 isolates. Of those studies, eight studies reported the distribution of S. pneumoniae serotypes among patients, three studies among healthy individuals, and five studies among both groups. As the meta-analysis revealed, the most common serotypes were 23F (n = 299, 14.1% [95% CI: 9.7-19.9]; I2 = 84.3%; P<0.001 for heterogeneity), 19F (n = 221, 13.4% [95% CI: 9.9-17.9; I2 = 76.7%; P<0.001 for heterogeneity]), and 19A (n = 102, 8.7% [95% CI: 6.5-11.7; I2 = 54.3%; P<0.001 for heterogeneity]). Moreover, Begg's test (P = 0.160, 0.173, and 0.176 for 23F, 19F, and 19A, respectively) showed no evidence of publication bias.
Conclusion: Based on our pooled results, the majority of the serotypes of pneumococci in the Iranian population were 23F, 19F, and 19A, respectively, over the last decade. The findings can be valuable in selecting effective pneumococcal vaccine candidates and targeted antibiotics in Iranian patients.
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