细胞内细菌对宿主脂质的操纵:免疫逃避的月光。

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Membrane Biology Pub Date : 2023-12-01 Epub Date: 2023-11-08 DOI:10.1007/s00232-023-00296-8
Naveen Challagundla, Deepti Phadnis, Aakriti Gupta, Reena Agrawal-Rajput
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引用次数: 0

摘要

脂质是满足能量需求的复杂有机分子,有时充当信号分子。它们大多存在于膜中,因此在膜运输和保护细胞免受外部危险方面发挥着重要作用。根据脂质的组成、流动性和电荷,它们与嵌入蛋白质的相互作用差异很大。细菌可以劫持宿主脂质以满足其能量需求或向宿主细胞隐藏自己。细胞内细菌不断利用宿主,从利用宿主脂质机制进入宿主细胞到通过细胞离开。从宿主细胞中获取脂质有助于它们的伪装机制。目前的综述探讨了细胞内细菌操纵和获取宿主脂质的各种机制。它讨论了它们在操纵宿主膜中的作用以及随后对宿主细胞的影响。调节巨噬细胞中的这些脂质不仅可以达到病原体的目的,还可以调节巨噬细胞的能量代谢和功能状态。此外,我们还探索了复杂的致病关系,以及将这一知识用于基于脂质的治疗以破坏病原体优势的潜在前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Host Lipid Manipulation by Intracellular Bacteria: Moonlighting for Immune Evasion.

Host Lipid Manipulation by Intracellular Bacteria: Moonlighting for Immune Evasion.

Lipids are complex organic molecules that fulfill energy demands and sometimes act as signaling molecules. They are mostly found in membranes, thus playing an important role in membrane trafficking and protecting the cell from external dangers. Based on the composition of the lipids, their fluidity and charge, their interaction with embedded proteins vary greatly. Bacteria can hijack host lipids to satisfy their energy needs or to conceal themselves from host cells. Intracellular bacteria continuously exploit host, from their entry into host cells utilizing host lipid machinery to exiting through the cells. This acquisition of lipids from host cells helps in their disguise mechanism. The current review explores various mechanisms employed by the intracellular bacteria to manipulate and acquire host lipids. It discusses their role in manipulating host membranes and the subsequence impact on the host cells. Modulating these lipids in macrophages not only serve the purpose of the pathogen but also modulates the macrophage energy metabolism and functional state. Additionally, we have explored the intricate pathogenic relationship and the potential prospects of using this knowledge in lipid-based therapeutics to disrupt pathogen dominance.

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来源期刊
Journal of Membrane Biology
Journal of Membrane Biology 生物-生化与分子生物学
CiteScore
4.80
自引率
4.20%
发文量
63
审稿时长
6-12 weeks
期刊介绍: The Journal of Membrane Biology is dedicated to publishing high-quality science related to membrane biology, biochemistry and biophysics. In particular, we welcome work that uses modern experimental or computational methods including but not limited to those with microscopy, diffraction, NMR, computer simulations, or biochemistry aimed at membrane associated or membrane embedded proteins or model membrane systems. These methods might be applied to study topics like membrane protein structure and function, membrane mediated or controlled signaling mechanisms, cell-cell communication via gap junctions, the behavior of proteins and lipids based on monolayer or bilayer systems, or genetic and regulatory mechanisms controlling membrane function. Research articles, short communications and reviews are all welcome. We also encourage authors to consider publishing ''negative'' results where experiments or simulations were well performed, but resulted in unusual or unexpected outcomes without obvious explanations. While we welcome connections to clinical studies, submissions that are primarily clinical in nature or that fail to make connections to the basic science issues of membrane structure, chemistry and function, are not appropriate for the journal. In a similar way, studies that are primarily descriptive and narratives of assays in a clinical or population study are best published in other journals. If you are not certain, it is entirely appropriate to write to us to inquire if your study is a good fit for the journal.
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