硒对重铬酸钾暴露于成年白化病大鼠视觉皮层的可能保护作用。

IF 1.1 4区 医学 Q4 MICROSCOPY
Ultrastructural Pathology Pub Date : 2023-11-02 Epub Date: 2023-11-30 DOI:10.1080/01913123.2023.2259455
Sally S Anwer, Hala Mohamed Hassanin
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引用次数: 0

摘要

视觉皮层在哺乳动物处理视觉信息方面非常重要。接触重铬酸钾等重金属对人类健康构成严重威胁。本工作的目的是研究重铬酸钾对成年白化大鼠视觉皮层的影响,并确定硒作为重铬酸钾毒性保护剂的可能性。总共使用了40只体重(200-250)克的成年白化大鼠。他们分为四组:对照组、重铬酸钾治疗组、重铬酸钾加硒治疗组和硒治疗组。大鼠接受6 周。6周后处死。本研究表明,重铬酸钾可导致IV层颗粒神经元和V层锥体神经元变性。形态计量学结果显示,与对照组相比,接受重铬酸钾治疗组的颗粒细胞和锥体细胞数量在统计学上显著减少。硒能改善大多数退行性变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The possible protective role of selenium on the visual cortex of adult albino rat on exposure to potassium dichromate.

The visual cortex is very important in mammals for processing of visual information. Exposure to heavy metals such as potassium dichromate poses serious health threat to human beings. The aim of this work is to study the effect of potassium dichromate on the visual cortex of adult albino rat and also to identify the possibility of selenium as protective agent against toxicity of potassium dichromate. A total number of 40 adult albino rats weighting (200-250) gm were used. They divided into four groups: control group, potassium dichromate received group, potassium dichromate and selenium received group and selenium received group. The rats received treatment for 6 weeks. After 6 weeks, they were sacrificed. The present study showed that potassium dichromate causes degeneration of granular neurons in layer IV and pyramidal neurons in layer V. Morphometric results revealed statistically significant decrease in the number of granule and pyramidal cells in potassium dichromate received group as compared with control group. Most of degenerative changes are improved by selenium.

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来源期刊
Ultrastructural Pathology
Ultrastructural Pathology 医学-病理学
CiteScore
2.00
自引率
10.00%
发文量
40
审稿时长
6-12 weeks
期刊介绍: Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.
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