克罗恩病患者血清肌酸酐水平的虚假升高而无组织学肾损伤:一例病例报告和文献综述。

IF 1.3 Q3 UROLOGY & NEPHROLOGY
Sul A Lee, Gearoid Michael McMahon
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引用次数: 0

摘要

炎症性肠病(IBD)患者容易发生肾损伤。IBD患者的肾脏受累通常通过测量血清肌酐和估计肾小球滤过率来诊断。我们描述了一名IBD患者,其血清肌酸酐水平波动较大(约3.0倍),无明显组织学异常,胱抑素C水平正常。这似乎与高蛋白饮食和间歇性禁食有关。尽管已经描述了高蛋白饮食对血清肌酐水平轻度升高的影响,但从未报道过单独饮食对血清肌酸酐的大幅波动,如本例所示,这引发了炎症肠道对肌酸酐肠道吸收或代谢的潜在影响的问题。该病例强调了详细病史的重要性,包括当遇到血清肌酸酐水平升高的患者时的饮食习惯,以及对肌酸酐高蛋白饮食或潜在IBD患者的血清肌酸酐的仔细解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A spurious elevation of serum creatinine level in a patient with Crohn's disease without histologic kidney damage: a case report and review of the literature.

Patients with inflammatory bowel disease (IBD) are prone to develop kidney injury. Renal involvement in IBD patients is usually diagnosed by the measurement of serum creatinine and the estimation of the glomerular filtration rate. We describe a patient with IBD who presented with large fluctuations in his serum creatinine level (~3.0-fold) without significant histologic abnormalities and with a normal cystatin C level. This appears to be related to a high-protein diet and intermittent fasting. Even though the impact of a high-protein diet on mild elevations of the serum creatinine level has been described, large fluctuations in serum creatinine from diet alone, as seen in this case, have never been reported, raising the question about the potential contribution of inflamed bowel on gut absorption or metabolism of creatinine. This case highlights the importance of a detailed history, including the dietary habits, when encountering a patient with increased serum creatinine level, and careful interpretation of serum creatinine in a patient with a creatinine high-protein diet or underlying IBD.

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来源期刊
CiteScore
2.20
自引率
16.70%
发文量
208
审稿时长
16 weeks
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