髋臼唇病变手术治疗相关报告结果的统计脆性分析。

IF 1.3 4区 医学 Q3 ORTHOPEDICS
HIP International Pub Date : 2024-03-01 Epub Date: 2023-11-06 DOI:10.1177/11207000231199387
Rahul Bhale, Michael Kain
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引用次数: 0

摘要

引言:本研究的目的是分析比较研究的稳健性,该研究评估了关节镜下唇重建与其他唇病理外科治疗的对比研究。统计脆弱性的关键指标包括脆弱性指数和脆弱性商。方法:本研究包括12项评估关节镜下唇重建使用的比较研究。特别关注评估功能改善、并发症发生率、全髋关节置换术(THA)需求和翻修率(相关p值)的趋势,无论是否具有统计学意义。本研究中涉及的分析是脆弱性指数,这是改变特定结果的统计显著性从而改变研究结论所需的事件的中位数。每项研究的脆性商计算为脆性指数除以样本量。结果:在纳入分析的12项研究中,共有25项报告的结果,其中8项具有统计学意义(p 结论:这项研究表明,关于唇重建关节镜技术的比较研究可能不像以前希望的那样在统计上稳定。在许多报告的结果中,特别是那些具有统计学意义的结果,只需要一小部分事件变化就可以改变研究结论的显著性。这种脆弱性令人担忧,因为依赖于这些报告结果的临床决策可能会对患者的长期结果产生重大影响。因此,通过结合过去的文献和报告的结果来优化患者的结果是至关重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Statistical fragility analysis of reported outcomes associated with surgical management of acetabular labral pathology.

Introduction: The purpose of this study was to analyse the robustness of comparative research that evaluated arthroscopic labral reconstruction versus other surgical management of labral pathology. Key measures of statistical fragility include the fragility index and fragility quotient.ß.

Methods: 12 comparative studies that evaluated the use of arthroscopic labral reconstruction were included in this study. Particular attention was placed on evaluating trends, either statistically significant or not, of functional improvement, complication rates, need for total hip arthroplasty (THA) and revision rates with associated p-values. The analysis involved in this study was the Fragility Index, which is the median number of events required to change the statistical significance of a particular outcome, thus changing the study conclusions. Fragility quotient was calculated for each study as the fragility index divided by sample size.

Results: Of the 12 studies that were included for analysis, there were a total of 25 reported outcomes, 8 of which were statistically significant (p < 0.05). The statistical fragility for the significant outcomes were 2.5 (interquartile range [IQR]: 1.5-3.5), whereas the median statistical fragility for insignificant results was 6 (IQR 4-9). The overall fragility index was 4 (IQR 3-7). The median of fragility quotients was 0.04 (IQR 0.01-0.07).

Conclusions: This study demonstrated that comparative research regarding arthroscopic techniques of labral reconstruction may not be as statistically stable as previously hoped. In many of the reported outcomes, particularly the ones that were statistically significant, only a small percentage of event changes was required to change the significance of the study conclusions. This fragility is worrisome, since clinical decisions that rely on these reported outcomes may have a significant impact on long-term patient outcomes. It is, therefore, crucial to optimise patient outcomes by incorporating past literature and reported outcomes.

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来源期刊
HIP International
HIP International 医学-整形外科
CiteScore
4.20
自引率
0.00%
发文量
70
审稿时长
2 months
期刊介绍: HIP International is the official journal of the European Hip Society. It is the only international, peer-reviewed, bi-monthly journal dedicated to diseases of the hip. HIP International considers contributions relating to hip surgery, traumatology of the hip, prosthetic surgery, biomechanics, and basic sciences relating to the hip. HIP International invites reviews from leading specialists with the aim of informing its readers of current evidence-based best practice. The journal also publishes supplements containing proceedings of symposia, special meetings or articles of special educational merit. HIP International is divided into six independent sections led by editors of the highest scientific merit. These sections are: • Biomaterials • Biomechanics • Conservative Hip Surgery • Paediatrics • Primary and Revision Hip Arthroplasty • Traumatology
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