预测溃疡性结肠炎患者在一年内发展为急性重症的风险模型的开发和验证。

IF 3.8 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Jie Chen, Yue Zhang, Qiong Guo, Tianqi Ren, Nana Tang, Han Chen, Hongjie Zhang
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引用次数: 0

摘要

背景和目的:急性严重溃疡性结肠炎(ASUC)与不良预后密切相关。我们的目标是建立和验证一个预测ASUC在1 溃疡性结肠炎(UC)诊断后一年。方法:对2018年至2020年在苏北人民医院确诊的UC患者进行一年的随访,建立风险预测模型。2021年1月至12月在(南京医科大学)监测至2022年12月的一个独立队列用于外部验证。进行了多变量逻辑回归分析,以调查六个风险因素与ASUC之间的调整相关性。随后,通过消除一个相对微不足道的风险因素,开发了一个简化模型,以创建一个易于使用的指数。结果:预测模型包含五个参数:疾病程度、内镜外观、组织病理学、基线反应药物和复发频率。它最终生成了一个列线图。在开发和验证队列中,判别能力(c指数)分别计算为0.982和0.925。结论:一年内开发ASUC的风险预测模型具有良好的可靠性和有效性,可作为预测1年内ASUC发生的直接且有临床价值的工具 年临床试验注册号:ChiCTR230071794。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and validation of a risk model to predict the progression of ulcerative colitis patients to acute severe disease within one year.

Background and aims: Acute severe ulcerative colitis (ASUC) is strongly associated with poor prognosis. We aimed to establish and validate a model predicting ASUC occurrence within 1 year after ulcerative colitis(UC) diagnosis.

Methods: A cohort of UC patients diagnosed between 2018 and 2020 at Northern Jiangsu People's Hospital, who were followed up for one year, was used to develop a risk prediction model. An independent cohort from January to December 2021, monitored until December 2022 at the at the First Affiliated Hospital of Nanjing Medical University, was used for external validation. A multivariable logistic regression analysis was conducted to investigate the adjusted association between six risk factors and ASUC. Subsequently, a simplified model was developed by eliminating a relatively insignificant risk factor to create an easy-to-use index.

Results: The prediction model incorporates five parameters: disease extent, endoscopic appearance, histopathology, baseline response medication, and relapse frequency. It generates a nomogram in the end. The discriminant ability (c-index) was separately calculated as 0.982 and 0.925 in the development and validation cohorts.

Conclusions: The risk prediction model for developing ASUC within one year demonstrated excellent reliability and validity, which could be a straightforward and clinically valuable tool for predicting ASUC occurrence within 1 year.

Clinical trial registration: ChiCTR2300071794.

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来源期刊
Expert Review of Gastroenterology & Hepatology
Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.80
自引率
2.60%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.
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