癌症患者经皮左心耳封堵术的应用及近期疗效。

IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Yaqi Zhang, Zhuoran Yang, Muhammad U Almani, Raquel Soon-Shiong, Bolun Liu
{"title":"癌症患者经皮左心耳封堵术的应用及近期疗效。","authors":"Yaqi Zhang,&nbsp;Zhuoran Yang,&nbsp;Muhammad U Almani,&nbsp;Raquel Soon-Shiong,&nbsp;Bolun Liu","doi":"10.1186/s40959-023-00192-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Percutaneous left atrial appendage occlusion (LAAO) has been rapidly evolving since FDA's approval in 2015 and has become more of a same-day-discharge procedure. Cancer patient with atrial fibrillation/flutter (AF) population can benefit from the procedure but the in-hospital outcomes and readmission data were rarely studied.</p><p><strong>Objectives: </strong>We investigated the utilization, in-hospital and readmission outcomes in cancer patients with AF who underwent LAAO.</p><p><strong>Methods: </strong>Data were derived from the National Inpatient Sample and National Readmissions Database from 2016 to 2019. Patients with primary diagnosis of AF admitted for LAAO (ICD-10 code 02L73DK) were grouped by cancer as a secondary diagnosis. We assessed in-hospital mortality, length of stay, total hospital charges, and complications. Thirty-day readmission rates were compared.</p><p><strong>Results: </strong>LAAO was performed in 60,380 patients with AF and 3% were cancer patients. There were no differences in in-hospital mortality and total hospital charges; however, cancer patients tended to have longer hospital stay (1.59 ± 0.11 vs. 1.32 ± 0.02, p = 0.013). Among complications, cancer patients had higher rates in open or percutaneous pericardial drainage (adjusted odds ratio [aOR] 2.38; 95% confidence interval [CI] 1.19-4.76) and major bleeding events (aOR 7.07; 95% CI 1.82-27.38). There was no statistical significance of 30-day readmission rates between patients with and without cancer (10.0% vs. 9.1%, p = 0.34). The most common readmission reason in cancer patients was gastrointestinal bleeding.</p><p><strong>Conclusions: </strong>LAAO is a promising procedure in cancer patients complicated by AF with contraindication to anticoagulation. Readmission rate is comparable between patients with and without cancer.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625234/pdf/","citationCount":"0","resultStr":"{\"title\":\"Utilization and short-term outcomes of percutaneous left atrial appendage occlusion in patients with cancer.\",\"authors\":\"Yaqi Zhang,&nbsp;Zhuoran Yang,&nbsp;Muhammad U Almani,&nbsp;Raquel Soon-Shiong,&nbsp;Bolun Liu\",\"doi\":\"10.1186/s40959-023-00192-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Percutaneous left atrial appendage occlusion (LAAO) has been rapidly evolving since FDA's approval in 2015 and has become more of a same-day-discharge procedure. Cancer patient with atrial fibrillation/flutter (AF) population can benefit from the procedure but the in-hospital outcomes and readmission data were rarely studied.</p><p><strong>Objectives: </strong>We investigated the utilization, in-hospital and readmission outcomes in cancer patients with AF who underwent LAAO.</p><p><strong>Methods: </strong>Data were derived from the National Inpatient Sample and National Readmissions Database from 2016 to 2019. Patients with primary diagnosis of AF admitted for LAAO (ICD-10 code 02L73DK) were grouped by cancer as a secondary diagnosis. We assessed in-hospital mortality, length of stay, total hospital charges, and complications. Thirty-day readmission rates were compared.</p><p><strong>Results: </strong>LAAO was performed in 60,380 patients with AF and 3% were cancer patients. There were no differences in in-hospital mortality and total hospital charges; however, cancer patients tended to have longer hospital stay (1.59 ± 0.11 vs. 1.32 ± 0.02, p = 0.013). Among complications, cancer patients had higher rates in open or percutaneous pericardial drainage (adjusted odds ratio [aOR] 2.38; 95% confidence interval [CI] 1.19-4.76) and major bleeding events (aOR 7.07; 95% CI 1.82-27.38). There was no statistical significance of 30-day readmission rates between patients with and without cancer (10.0% vs. 9.1%, p = 0.34). The most common readmission reason in cancer patients was gastrointestinal bleeding.</p><p><strong>Conclusions: </strong>LAAO is a promising procedure in cancer patients complicated by AF with contraindication to anticoagulation. Readmission rate is comparable between patients with and without cancer.</p>\",\"PeriodicalId\":9804,\"journal\":{\"name\":\"Cardio-oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2023-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625234/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardio-oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s40959-023-00192-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardio-oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40959-023-00192-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

摘要

背景:自2015年美国食品药品监督管理局批准以来,经皮左心耳封堵术(LAAO)一直在快速发展,并已成为更多的当天出院程序。患有心房颤动/扑动(AF)人群的癌症患者可以从该手术中受益,但住院结果和再入院数据很少研究。目的:我们调查了接受LAAO的癌症房颤患者的利用率、住院和再入院结果。方法:数据来源于2016年至2019年全国住院患者样本和全国自述数据库。原发诊断为房颤的LAAO患者(ICD-10代码02L73DK)按癌症分组作为二级诊断。我们评估了住院死亡率、住院时间、总住院费用和并发症。比较了30天的再入院率。结果:60380例房颤患者行LAAO,3%为癌症患者。住院死亡率和总住院费用没有差异;然而,癌症患者的住院时间往往更长(1.59 ± 0.11对1.32 ± 0.02,p = 在并发症中,癌症患者有较高的开放或经皮心包引流率(调整比值比[aOR]2.38;95%置信区间[CI]1.19-4.76)和主要出血事件(aOR7.07;95%CI1.82-27.38) = 癌症患者最常见的再入院原因是消化道出血。结论:对于有抗凝禁忌证的癌症合并房颤患者,LAAO是一种很有前途的治疗方法。癌症和非癌症患者的再移植率相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Utilization and short-term outcomes of percutaneous left atrial appendage occlusion in patients with cancer.

Utilization and short-term outcomes of percutaneous left atrial appendage occlusion in patients with cancer.

Utilization and short-term outcomes of percutaneous left atrial appendage occlusion in patients with cancer.

Background: Percutaneous left atrial appendage occlusion (LAAO) has been rapidly evolving since FDA's approval in 2015 and has become more of a same-day-discharge procedure. Cancer patient with atrial fibrillation/flutter (AF) population can benefit from the procedure but the in-hospital outcomes and readmission data were rarely studied.

Objectives: We investigated the utilization, in-hospital and readmission outcomes in cancer patients with AF who underwent LAAO.

Methods: Data were derived from the National Inpatient Sample and National Readmissions Database from 2016 to 2019. Patients with primary diagnosis of AF admitted for LAAO (ICD-10 code 02L73DK) were grouped by cancer as a secondary diagnosis. We assessed in-hospital mortality, length of stay, total hospital charges, and complications. Thirty-day readmission rates were compared.

Results: LAAO was performed in 60,380 patients with AF and 3% were cancer patients. There were no differences in in-hospital mortality and total hospital charges; however, cancer patients tended to have longer hospital stay (1.59 ± 0.11 vs. 1.32 ± 0.02, p = 0.013). Among complications, cancer patients had higher rates in open or percutaneous pericardial drainage (adjusted odds ratio [aOR] 2.38; 95% confidence interval [CI] 1.19-4.76) and major bleeding events (aOR 7.07; 95% CI 1.82-27.38). There was no statistical significance of 30-day readmission rates between patients with and without cancer (10.0% vs. 9.1%, p = 0.34). The most common readmission reason in cancer patients was gastrointestinal bleeding.

Conclusions: LAAO is a promising procedure in cancer patients complicated by AF with contraindication to anticoagulation. Readmission rate is comparable between patients with and without cancer.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Cardio-oncology
Cardio-oncology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
5.00
自引率
3.00%
发文量
17
审稿时长
7 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信